77-27-0 Usage
Description
5-ALLYL-5-[1-METHYLBUTYL]-2-THIOBARBITURIC ACID, also known as Thiamylal, is a barbiturate derivative characterized by its sedative, anticonvulsant, and hypnotic properties. It is a controlled substance due to its potential for abuse and dependence.
Used in Pharmaceutical Industry:
5-ALLYL-5-[1-METHYLBUTYL]-2-THIOBARBITURIC ACID is used as an anesthetic agent for the induction of surgical anesthesia. It helps to rapidly induce a state of unconsciousness, allowing for the safe and effective administration of surgical procedures.
5-ALLYL-5-[1-METHYLBUTYL]-2-THIOBARBITURIC ACID is also used as an anticonvulsant medication to counteract the side effects of other anesthetics. Its anticonvulsant properties help to prevent and treat seizures, making it a valuable asset in the management of various neurological conditions.
Originator
Surital,Parke Davis,US,1951
Manufacturing Process
In 450 cc of methanol is added 47 grams of sodium metal and the mixture
allowed to completely react to form a methanol solution of sodium methoxide.
The methanol solution of sodium methoxide is then cooled to 60°C and 68
grams of thiourea which has been thoroughly dried is added with stirring until
a uniform solution is formed. Thereafter, 157 grams of diethyl allyl-(1-
methylbutyl)malonate is added to the solution of the sodio derivative of
thiourea at a temperature of 55°C and the condensation reaction mixture
maintained at the said temperature for 24 hours. Methyl alcohol is removed
under vacuum during the course of the reaction while maintaining a
temperature of 55°C.The viscous reaction mixture is then poured into 1.5 liters of ice water and
agitated to form a uniform solution. The solution is treated with activated
carbon and filtered. Thereafter, 80% acetic acid is added until the filtered
solution remains acidic to litmus. The precipitate formed is filtered and
washed thoroughly with distilled water. The product is air-dried at a temperature of 95° to 100°C for 48 hours to yield 133 grams of 5-allyl-5-(1-
methylbutyl)-2-thiobarbituric acid having a melting point of 132° to 133°C
and assaying at 99.5% pure, from US Patent 2,876,225.
Check Digit Verification of cas no
The CAS Registry Mumber 77-27-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 77-27:
(4*7)+(3*7)+(2*2)+(1*7)=60
60 % 10 = 0
So 77-27-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)
77-27-0Relevant articles and documents
Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury
-
, (2008/06/13)
Methods and compositions are described for treatment to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an alkenyl-substituted or alkynyl-substituted thiobarbiturate characterized in having broad-spectrum activity as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.