770-23-0

Basic information

• Product Name: 2-Propenal, 3-(3-chlorophenyl)-
• CAS NO: 770-23-0
• Molecular Formula: C9H7ClO
• Molecular Weight: 166.607
• Mol File: 770-23-0.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 2-Propenal, 3-(3-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 3-(3-chlorophenyl)-(770-23-0)
• EPA Substance Registry System: 2-Propenal, 3-(3-chlorophenyl)-(770-23-0)

Safety Data

• Hazardous Substances Data: 770-23-0(Hazardous Substances Data)

Usage

Chemical compound

2-Propenal, 3-(3-chlorophenyl)-

Classification

α,β-unsaturated aldehyde

Physical properties

yellowish liquid, sparingly soluble in water

Main use

intermediate in the production of pharmaceuticals and agricultural chemicals

Toxic effects

potential irritant to skin, eyes, and respiratory system

Safety precautions

handle with caution, follow safety guidelines and regulations

Upstream product

• 1504-67-2 3-(3-chlorophenyl)prop-2-en-1-ol 
• 64-17-5 ethanol 
• 873-63-2 m-chlorobenzyl alcohol 
• 587-04-2 m-Chlorobenzaldehyde 
• 29805-12-7 1-(3-chlorophenyl)-2-propyn-1-ol 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 
• 58824-53-6 1-(3-chlorophenyl)prop-2-en-1-ol 
• 1258237-13-6 (E)-(3-chlorostyryl)boronic acid 
• 298-12-4 Glyoxilic acid 
• 3840-17-3 1-allyl-3-chlorobenzene 
• 108-37-2 1-bromo-3-chlorobenzene 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 201230-82-2 carbon monoxide 
• 766-83-6 m-chlorophenylacetylene 

Downstream Products

• 1100803-82-4 methyl 2-((1S,2S,3R,4R)-3-(3-chlorophenyl)-2-formyl-4-nitrocyclopentyl)acetate 
• 1262775-61-0 1,1,1-trichloro-4-(3-chlorophenyl)but-(E)-3-en-2-ol 
• 1280227-03-3 methyl (2R,3S,4aS)-3-(3-chlorophenyl)-1-oxo-1,2,3,4,4a-pentahydrobenzo[d]pyrido[2,1-b]oxazol-2-carboxylate 
• 1220981-15-6 (R)-dimethyl 2-(1-(3-chlorophenyl)-2-formylethyl)malonate 
• 1332624-52-8 (S)-ethyl 4-(3-chlorophenyl)-6-hydroxy-3,4-dihydro-2H-pyran-5-carboxylate 
• 1402544-79-9 (4S,5R)-ethyl 5-nitro-4-(3-chlorophenyl)cyclohex-1-enecarboxylate 
• 1426928-98-4 methyl (2S,3R)-3-(3-chlorophenyl)oxirane-2-carboxylate 

Relevant articles and documents

NOVEL COMPOUNDS USEFUL AS NEAR-INFRARED FLUORESCENT PROBES SELECTIVELY BINDING TO TAU AGGREGATES AND METHOD OF PREPARING THE SAME

Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

Enantioselective Organocatalytic Synthesis of 1,2,3-Trisubstituted Cyclopentanes

An organocatalytic asymmetric domino Michael/α-alkylation reaction between enals and non-stabilized alkyl halides has been developed. Chiral secondary amine catalyzed cyclization reaction of 1-bromo-3-nitropropane with α,β-unsaturated aldehydes provides 1,2,3-trisubstituted cyclopentane carbaldehydes with high diastereo- (dr up to 8 : 1) and enantioselectivities (ee up to 96 %).

Selective Rhodium-Catalyzed Hydroformylation of Terminal Arylalkynes and Conjugated Enynes to (Poly)enals Enabled by a π-Acceptor Biphosphoramidite Ligand

The hydroformylation of terminal arylalkynes and enynes offers a straightforward synthetic route to the valuable (poly)enals. However, the hydroformylation of terminal alkynes has remained a long-standing challenge. Herein, an efficient and selective Rh-catalyzed hydroformylation of terminal arylalkynes and conjugated enynes has been achieved by using a new stable biphosphoramidite ligand with strong π-acceptor capacity, which affords various important E-(poly)enals in good yields with excellent chemo- and regioselectivity at low temperatures and low syngas pressures.