770719-09-0

Basic information

• Product Name: 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile
• Synonyms: 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile
• CAS NO: 770719-09-0
• Molecular Weight: 310.644
• Mol File: 770719-09-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile(770719-09-0)
• EPA Substance Registry System: 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile(770719-09-0)

Safety Data

• Hazardous Substances Data: 770719-09-0(Hazardous Substances Data)

Upstream product

• 771-69-7 2,3,4-trifluoronitrobenzene 
• 473923-97-6 3-chloro-5-hydroxybenzonitrile 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 473923-96-5 3-chloro-5-methoxybenzonitrile 

Downstream Products

• 1093254-65-9 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-benzofuran-2-carboxamide 
• 1093254-98-8 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1-methyl-1H-imidazole-5-carboxamide 
• 1093259-37-0 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-methyl-1H-imidazole-5-carboxamide 
• 1093256-51-9 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-(trifluoromethyl)-1H-imidazole-5-carboxamide 
• 1414973-11-7 C₁₉H₁₀Cl₂F₄N₄O₂*C₂HF₃O₂ 
• 1093255-92-5 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide 
• 1093349-42-8 C₁₈H₁₀BrCl₂FN₄O₂*C₂HF₃O₂ 
• 1093349-48-4 C₁₉H₁₂Cl₃FN₄O₂ 
• 1093255-18-5 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-2-ethyl-1H-imidazole-5-carboxamide 
• 1093349-49-5 4-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-2-propyl-1H-imidazole-5-carboxamide 
• 1093259-90-5 5-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-2-oxo-2,3-dihydro-1H-imidazole-4-carboxamide 
• 1093257-12-5 C₁₈H₁₁Cl₃FN₅O₂ 
• 1093260-75-3 3-chloro-5-[(2-fluoro-3-methyl-6-nitrophenyl)oxy]benzonitrile 
• 1093260-77-5 3-[(6-amino-2-fluoro-3-methylphenyl)oxy]-5-chlorobenzonitrile 

Relevant articles and documents

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ray crystallography of inhibitors bound to reverse transcriptase, including a structure of the Y188L RT protein, was used extensively to help identify and optimize the key hydrogen-bonding motif. This led directly to the design of compound 43 that exhibits remarkable antiviral activity (EC50 1 nM) against a wide range of NNRTI-resistant viruses and a favorable pharmacokinetic profile across multiple species.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.