77094-11-2 Usage
Chemical Properties
Yellow Crystalline Solid
Uses
Mutagenic heterocyclic amines in cooked food
Production Methods
Heterocyclic amines are formed by condensation of creatinine
with amino acids during heating or cooking of meat
(beef, pork, chicken, and fish). They have also been detected
in processed food flavorings, beer, wine, and cigarette smoke.
2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) and
related heterocyclic amines are produced in small quantities
for research purposes. Exposure to MeIQ and related
heterocyclic amines occurs primarily through the consumption
of cooked meats.Concentrations of heterocyclic
amines in meats varied under different cooking conditions
(375). The highest concentrations of MeIQ were
detected in grilled fish, which appear to be the major dietary
source of heterocyclic amines in Japanese. U.S. surveys
of dietary intakes of heterocyclic amines in cooked
foods have also been reported. Occupational exposure
to heterocyclic amines may occur by inhalation of aerosolized
particles formed during the cooking process.
General Description
Pale orange crystalline solid or light yellow powder.
Air & Water Reactions
2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE is sensitive to light and air. Slightly water soluble .
Reactivity Profile
2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE is rapidly degraded by dilute hypochlorite.
Health Hazard
ACUTE/CHRONIC HAZARDS: 2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE may emit potentially toxic fumes when involved in a fire.
Fire Hazard
Flash point data for 2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE are not available; however, 2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE is probably combustible.
Carcinogenicity
MeIQ is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting genotoxicity data.
Check Digit Verification of cas no
The CAS Registry Mumber 77094-11-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,9 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 77094-11:
(7*7)+(6*7)+(5*0)+(4*9)+(3*4)+(2*1)+(1*1)=142
142 % 10 = 2
So 77094-11-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H12N4/c1-7-6-9-8(4-3-5-14-9)10-11(7)16(2)12(13)15-10/h3-6H,1-2H3,(H2,13,15)
77094-11-2Relevant articles and documents
Synthetic Routes to the Carcinogen IQ and Related 3H-Imidazoquinolines
Ronne, Erik,Grivas, Spiros,Olsson, Kjell
, p. 823 - 830 (2007/10/02)
2-Amino-3-methyl-3H-imidazoquinoline (IQ, 1a) and four new IQ homologues, viz. its 7-methyl, 8-methyl, 9-methyl and 7,9-dimethyl derivatives 1c-1f, have been conveniently synthesized from the appropriate 6-methoxyquinolines 3 rather than from the p
Syntheses of 2-Amino-3,4-dimethyl-3H-imidazoquinoline and Its Related Compounds
Kasai, Hiroshi,Nishimura, Susumu
, p. 2233 - 2235 (2007/10/02)
The strongly mutagenic compound, 2-amino-3,4-dimethyl-3H-imidazoquinoline (Me-IQ), isolated from broiled sardines was synthesized from 6-amino-7-methylquinoline.Several structurally related compounds were also synthesized to clarify the structure-a
STRUCTURE AND CHEMICAL SYNTHESIS OF ME-IQ, A POTENT MUTAGEN ISOLATED FROM BROILED FISH
Kasai, Hiroshi,Yamaizumi, Ziro,Wakabayashi, Keiji,Nagao, Minako,Sugimura, Takashi,et al.
, p. 1391 - 1394 (2007/10/02)
Structure of a mutagenic compound (Me-IQ) isolated from broiled fish was determined to be 2-amino-3,4-dimethylimidazoquinoline based on the mass-, UV- and 1HNMR-spectra and chemical synthesis.Me-IQ showed strong mutagenic activity towards Salmonella typhimurium TA98 in the presence of S-9 mix.
