771-24-4

Basic information

• Product Name: 2(1H)-Quinoxalinone, 1-hydroxy-
• CAS NO: 771-24-4
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Mol File: 771-24-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinoxalinone, 1-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone, 1-hydroxy-(771-24-4)
• EPA Substance Registry System: 2(1H)-Quinoxalinone, 1-hydroxy-(771-24-4)

Safety Data

• Hazardous Substances Data: 771-24-4(Hazardous Substances Data)

Usage

Chemical class

Quinoxalinones

Type of compound

Heterocyclic

Structural feature

Contains a quinoxaline ring with a hydroxyethyl group at position 1

Biological activities

Anti-inflammatory and antioxidant properties

Potential use

Treatment of cancer and neurodegenerative diseases

Industrial application

Development of pharmaceutical drugs and as a building block in organic synthesis

Promising potential

Medicinal and scientific applications.

Upstream product

• 2423-66-7 quinoxaline 1,4-di-N-oxide 

Downstream Products

• 1196-57-2 quinoxalin-2⁽¹⁾-one 

Relevant articles and documents

Quinoxaline Derivatives. XII. The Reactions of Quinoxaline 1,4-Dioxides with Acetic Anhydride

Quinoxaline 1,4-dioxide (XIIIa) with acetic anhydride gave 1-acetoxy-2(1H)-quinoxalinone (XIVa) which was prone to facile hydrolysis to yield 1-hydroxy-2(1H)-quinoxalinone (XVa).Both XIVa and XVa were isolated from the reaction mixture.On prolonged heating with acetic anhydride, XIIIa, XIVa and XVa were converted slowly to the same end product, 2,3(1H,4H)-quinoxalinedione (XXa). 6-Ethoxy- (XIIIb), 6-methoxy- (XIIIc), and 6-methylquinoxaline 1,4-dioxide (XIIId) behaved similarly, except that the attack of the reagent took place exclusively on N-oxide para to the electron-donating substituents, and none of the other expected isomeric compounds XVIIb-d were isolated.Whereas 6-chloroqinoxaline 1,4-dioxide (XIIIe) bearing an electron-attracting chloro substituent on the benzene ring gave exclusively the other isomers XVIIe, XVIIIe, and XXe.A mechanism for this novel rearrangement is proposed and discussed.