771-99-3

Basic information

• Product Name: 4-Phenylpiperidine
• Synonyms: RARECHEM AH CK 0160;Piperidine, 4-phenyl-;TIMTEC-BB SBB003943;LABOTEST-BB LT00233204;LABOTEST-BB LTBB000705;AKOS BBS-00003581;4-Phenylpiperidine 97%;4-PHENYLPIPERDINE
• CAS NO: 771-99-3
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.24
• EINECS: 212-243-1
• Product Categories: Amines and Anilines;Piperidines, Piperidones, Piperazines;Piperidine;API intermediates;PYRIDINE;Building Blocks;Heterocyclic Building Blocks;Piperidines
• Mol File: 771-99-3.mol
• Article Data: 40

Chemical Properties

• Melting Point: 61-65 °C(lit.)
• Boiling Point: 286 °C(lit.)
• Flash Point: >230 °F
• Appearance: Yellow to brown/Powder
• Density: 1.062 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: n20/D 1.588(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.20±0.10(Predicted)
• Water Solubility: Soluble in water.
• BRN: 124508
• CAS DataBase Reference: 4-Phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenylpiperidine(771-99-3)
• EPA Substance Registry System: 4-Phenylpiperidine(771-99-3)

Safety Data

• Hazard Codes: T,Xi,C,F
• Statements: 36/37/38-34-11-20/21/22
• Safety Statements: 26-36/37/39-45-37/39-36/37-16
• RIDADR: UN 2922 8/PG 2
• WGK Germany: 3
• RTECS: TM2625000
• F: 10
• HazardClass: IRRITANT
• Hazardous Substances Data: 771-99-3(Hazardous Substances Data)

Usage

Description

4-Phenylpiperidine is a chemical compound characterized by a benzene ring bound to a piperidine ring. It serves as the base structure for a variety of opioids, including pethidine (meperidine), ketobemidone, alvimopan, loperamide, and diphenoxylate. This off-white to light brown crystalline powder is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals, and dyestuff.

Uses

Used in Pharmaceutical Industry:
4-Phenylpiperidine is used as a key intermediate for the synthesis of various opioids, which are essential in the development of medications for pain management and treatment of opioid addiction. Its presence in the molecular structure of these drugs contributes to their analgesic and therapeutic properties.
Used in Organic Synthesis:
4-Phenylpiperidine is used as a versatile building block in organic synthesis, allowing for the creation of a wide range of chemical compounds with diverse applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Phenylpiperidine is utilized as a starting material for the development of new pesticides and other agricultural chemicals, contributing to enhanced crop protection and yield.
Used in Dyestuff Industry:
4-Phenylpiperidine is employed as a crucial component in the production of various dyes and pigments, providing color and functionality to a range of products in the dyestuff industry.

InChI:InChI=1/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2/p+1

Upstream product

• 939-23-1 p-phenylpyridine 
• 14149-31-6 4-phenylpiperidine-2,6-dione 
• 873380-11-1 3-phenyl-glutaric acid bis-benzylamide 
• 51304-58-6 4-cyano-4-phenylpiperidine hydrochloride 
• 123-91-1 1,4-dioxane 
• 859981-72-9 3-phenyl-glutaric acid bis-phenethylamide 
• 38025-45-5 1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine 
• 63843-83-4 1-benzyl-4-hydroxy-4-phenylpiperidine 
• 37656-48-7 4-(4-fluorophenyl)piperidine 
• 143632-57-9 N-(toluenesulfonyl)-4-phenylpiperidine 
• 1450643-93-2 1,2-bis(4-phenylpiperidin-1-yl)ethane 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 186347-72-8 4-phenyl-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 108-86-1 bromobenzene 

Downstream Products

• 776-91-0 1-ethyl-4-phenylpiperidine 
• 14813-03-7 4-phenyl-1-propyl-piperidine 
• 774-52-7 1-methyl-4-phenylpiperidine 
• 16376-62-8 3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 34588-04-0 3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazole-2-thione 
• 23002-85-9 3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzothiazole-2-thione 
• 23002-89-3 5-chloro-3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzothiazole-2-thione 
• 33397-70-5 3-(4-phenyl-piperidin-1-yl)-rifamycin 
• 16376-63-9 5-chloro-3-(4-phenyl-piperidin-1-ylmethyl)-3H-benzooxazol-2-one 
• 56953-33-4 N-(β-idrossietil)-4-fenilpiperidina 
• 120447-50-9 (+/-)-N-(2-hydroxybutyl)-4-phenylpiperidine hydrochloride 
• 112611-57-1 (+/-)-trans-2-(4-phenylpiperidino)cyclopentanol 
• 134905-78-5 3-(4-bromophenyl)-2-hydroxy-1-[1-(4-phenylpiperidinyl)]propane 
• 70175-20-1 2,2'-bis-(4-phenyl-piperidin-1-yl)-N,N'-benzo[1,2-d;5,4-d']bisthiazole-2,6-diyl-bis-acetamide 

Relevant articles and documents

Method for preparing piperidine compound by reducing pyridine compound through hydrogen transfer

The invention discloses a method for preparing a piperazine compound through a hydrogen transfer reduction of a pyridine compound, belonging to the field of organic synthesis. Under mild conditions, pyridine derivatives are used as raw materials, oxazolidine is used as a hydrogen transfer reagent, and cheap transition metals such as copper, cobalt, silver, palladium and the like are used as catalysts for catalysis of a hydrogen transfer reaction on 1,2,3,4-substitution sites, so a series of hydrogen transfer reduction product piperidine compounds are prepared, wherein the oxazaborolidine is obtained by a reaction of amino acid with a tetrahydrofuran complex of borane. The method has the advantages that product yield is high, reaction conditions are mild, the general applicability of raw materials is good, a hydrogen transfer reagent is cheap and easy to obtain, and good reproducibility can still be shown after quantitative reaction is conudcted. Therefore, the method of the invention provides an effective scheme for the industrial production of other high-value compounds containing the structure in the future.

Cobalt-bridged secondary building units in a titanium metal-organic framework catalyze cascade reduction of N-heteroarenes

We report here a novel Ti3-BPDC metal-organic framework (MOF) constructed from biphenyl-4,4′-dicarboxylate (BPDC) linkers and Ti3(OH)2 secondary building units (SBUs) with permanent porosity and large 1D channels. Ti-OH groups from neighboring SBUs point toward each other with an O-O distance of 2 ?, and upon deprotonation, act as the first bidentate SBU-based ligands to support CoII-hydride species for effective cascade reduction of N-heteroarenes (such as pyridines and quinolines) via sequential dearomative hydroboration and hydrogenation, affording piperidine and 1,2,3,4-tetrahydroquinoline derivatives with excellent activity (turnover number ～ 1980) and chemoselectivity.

Hydrogenation of Pyridines Using a Nitrogen-Modified Titania-Supported Cobalt Catalyst

Novel heterogeneous catalysts were prepared by impregnation of titania with a solution of cobalt acetate/melamine and subsequent pyrolysis. The resulting materials show an unusual nitrogen-modified titanium structure through partial implementation of nitrogen into the support. The optimal catalyst displayed good activity and selectivity for challenging pyridine hydrogenation under acid free conditions in water as solvent.