77102-82-0 Usage
Description
3,3',4,4'-TETRABROMOBIPHENYL is a multi-persistent organic pollutant that is analyzed in breast milk of first-time mothers. It is derived from 1-Bromo-2-nitrobenzene (B686175), an organic building block used for the synthesis of various pharmaceutical compounds. It is also an intermediate for the synthesis of novel Diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.
Uses
Used in Environmental Analysis:
3,3',4,4'-TETRABROMOBIPHENYL is used as an environmental pollutant in the analysis of breast milk of first-time mothers, helping to identify and monitor the presence of this pollutant in the environment.
Used in Pharmaceutical Synthesis:
3,3',4,4'-TETRABROMOBIPHENYL is used as an intermediate in the synthesis of novel Diarylamino-1,3,5-triazine derivatives, which are FAK inhibitors with anti-angiogenic activity. This makes it a valuable component in the development of new pharmaceutical compounds for various therapeutic applications.
Used in Environmental Research:
3,3',4,4'-TETRABROMOBIPHENYL is used as a research tool to study the effects of environmental pollutants on copper and molybdenum metabolism in rats, providing insights into the potential health impacts of this pollutant on living organisms.
Check Digit Verification of cas no
The CAS Registry Mumber 77102-82-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,0 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 77102-82:
(7*7)+(6*7)+(5*1)+(4*0)+(3*2)+(2*8)+(1*2)=120
120 % 10 = 0
So 77102-82-0 is a valid CAS Registry Number.
77102-82-0Relevant articles and documents
Sterically controlled C-H/C-H homocoupling of arenes: Via C-H borylation
Pei, Xiaocong,Zhou, Guan,Li, Xuejing,Xu, Yuchen,Panicker, Resmi C.,Srinivasan, Rajavel
supporting information, p. 5703 - 5707 (2019/06/19)
A mild one-pot protocol for the synthesis of symmetrical biaryls by sequential Ir-catalyzed C-H borylation and Cu-catalyzed homocoupling of arenes is described. The regiochemistry of the biaryl formed is sterically controlled as dictated by the C-H borylation step. The methodology is also successfully extended to heteroarenes. Some of the products obtained by this approach are impossible to obtain via the Ullmann or the Suzuki coupling protocols. Finally, we have shown a one-pot sequence describing C-H borylation/Cu-catalyzed homocoupling/Pd-catalyzed Suzuki coupling to obtain π-extended arene frameworks.