77112-53-9

Basic information

• Product Name: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
• Synonyms: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID
• CAS NO: 77112-53-9
• Molecular Formula: C₇H₅N₃O₂
• Molecular Weight: 163.13
• Mol File: 77112-53-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 280 °C (decomp)
• Appearance: /
• Density: 1.585 g/cm³
• Refractive Index: 1.739
• Storage Temp.: 2-8°C
• PKA: -2.07±0.41(Predicted)
• CAS DataBase Reference: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID(77112-53-9)
• EPA Substance Registry System: IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID(77112-53-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77112-53-9(Hazardous Substances Data)

Usage

General Description

IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C7H5N3O2. It is an aromatic heterocyclic compound that contains both an imidazole and a pyrazine ring. IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs, such as antiviral and antibacterial agents. It is also utilized in academic research for the development of new medicinal compounds. IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID is known for its potential therapeutic properties and is a valuable intermediate in the production of various pharmaceuticals.

InChI:InChI=1/C7H5N3O2/c11-7(12)5-4-10-2-1-8-3-6(10)9-5/h1-4H,(H,11,12)

Upstream product

• 77112-52-8 ethyl imidazo[1,2-a]pyrazine-2-carboxylate 
• 5049-61-6 2-Aminopyrazine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 77112-52-8 ethyl imidazo[1,2-a]pyrazine-2-carboxylate 
• 623564-18-1 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride 
• 1250999-20-2 2-bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 
• 1227685-81-5 C₂₅H₂₆F₂N₈O₅ 

Relevant articles and documents

Green Synthesis and Antimicrobial Activity of Some Novel N-Arylimidazo[1,2-a]pyrazine-2-Carboxamide Derivatives

The article deals with the synthesis of some novel N-arylimidazo[1,2-a]pyrazine-2-carboxamides (7a-l) by condensation reaction of imidazo[1,2-a]pyrazine-2-carboxylic acid (5) with different aliphatic/aromatic amines (6a-l) by using 1-methylimidazole, Mukaiyama’s reagent and 2-chloro-1-methylpyridinium iodide under microwave irradiation conditions. A new series of compounds 7 have been prepared from 2-iodopyrazine (1). Compound 1 on purged with ammonia gas in the presence of Cu2O and K2CO3 furnishes pyrazin-2-amine (2), which is treated with ethyl 3-bromo-2-oxopropanoate (3) to produce ethyl imidazo[1,2-a]pyrazine-2-carboxylate (4), which on hydrolysis with NaOH yields imidazo[1,2-a]pyrazine-2-carboxylic acid (5). The structures of the newly synthesized compounds have been elucidated on the basis of spectral (IR, 1H and 13C NMR and MS) and analytical data. Compounds 7a-l have also been screened for their antimicrobial activity. Some of the compounds exhibit promising antimicrobial activity.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Research on heterocyclic compounds. X - Imidazo[1,2-a]pyrazine derivatives: synthesis and antiinflammatory activity

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