77123-59-2

Basic information

• Product Name: Methyl 3-((triMethylsilyl)ethynyl)benzoate
• Synonyms: Methyl 3-((triMethylsilyl)ethynyl)benzoate;2-(tritylthio)ethyl 3-((trimethylsilyl)ethynyl)benzoate
• CAS NO: 77123-59-2
• Molecular Formula: C₁₃H₁₆O₂Si
• Molecular Weight: 232.35044
• Mol File: 77123-59-2.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 3-((triMethylsilyl)ethynyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-((triMethylsilyl)ethynyl)benzoate(77123-59-2)
• EPA Substance Registry System: Methyl 3-((triMethylsilyl)ethynyl)benzoate(77123-59-2)

Safety Data

• Hazardous Substances Data: 77123-59-2(Hazardous Substances Data)

Usage

Description

Methyl 3-((triMethylsilyl)ethynyl)benzoate is a chemical compound with the molecular formula C13H16O2Si. It is a silyl-protected alkynyl benzoate, containing functional groups such as a methyl ester and an acetylene. Methyl 3-((triMethylsilyl)ethynyl)benzoate is known for its versatile reactivity and functional groups, making it a valuable component in various chemical processes.

Uses

Used in Organic Synthesis:
Methyl 3-((triMethylsilyl)ethynyl)benzoate is used as a key intermediate in organic synthesis for the preparation of various organic molecules and materials. Its unique structure allows for a wide range of reactions, making it a valuable building block in the synthesis of complex organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, Methyl 3-((triMethylsilyl)ethynyl)benzoate is used as a reagent in the production of various pharmaceuticals. Its functional groups and reactivity make it suitable for the synthesis of drug molecules, contributing to the development of new medications.
Used in Agrochemical Production:
Methyl 3-((triMethylsilyl)ethynyl)benzoate also finds application in the agrochemical industry, where it is used in the synthesis of various agrochemicals. Its versatility in chemical reactions allows for the creation of compounds that can be used in agriculture to improve crop yields and protect plants from pests.
Used in Materials Science:
In the field of materials science, Methyl 3-((triMethylsilyl)ethynyl)benzoate is utilized for the development of new materials with unique properties. Its ability to participate in a variety of chemical reactions enables the creation of materials with specific characteristics, such as improved strength, flexibility, or chemical resistance.

Upstream product

• 618-89-3 methyl 3-bromobenzoate 
• 1066-54-2 trimethylsilylacetylene 
• 618-91-7 methyl 3-iodo-benzoate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 618-51-9 3-Iodobenzoic acid 

Downstream Products

• 10602-06-9 methyl 3-ethynylbenzoate 
• 21860-07-1 methyl 3-acetylbenzoate 
• 1173153-25-7 3-(2-aminophenylethynyl)benzoic acid methyl ester 
• 1364421-76-0 3-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid methyl ester 
• 1364421-80-6 3-{3-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid methyl ester 
• 1364421-84-0 3-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid 
• 1364421-88-4 3-{3-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid 
• 930396-02-4 3-(3-aminophenylethynyl)benzoic acid methyl ester 

Relevant articles and documents

Chemoselective Cleavage of Si-C(sp3) Bonds in Unactivated Tetraalkylsilanes Using Iodine Tris(trifluoroacetate)

Organosilanes are synthetically useful reagents and precursors in organic chemistry. However, the typical inertness of unactivated Si-C(sp3) bonds under conventional reaction conditions has hampered the application of simple tetraalkylsilanes in organic synthesis. Herein we report the chemoselective cleavage of Si-C(sp3) bonds of unactivated tetraalkylsilanes using iodine tris(trifluoroacetate). The reaction proceeds smoothly under mild conditions (-50 °C to room temperature) and tolerates various polar functional groups, thus enabling subsequent Tamao-Fleming oxidation to provide the corresponding alcohols. NMR experiments and density functional theory calculations on the reaction indicate that the transfer of alkyl groups from Si to the I(III) center and the formation of the Si-O bond proceed concertedly to afford an alkyl-λ3-iodane and silyl trifluoroacetate. The developed method enables the use of unactivated tetraalkylsilanes as highly stable synthetic precursors.

NOVEL INDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING CANCER CONTAINING THE SAME

Disclosed are a compound selected from novel indazole derivatives, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, and a pharmaceutical composition for preventing, alleviating or treating cancer containing the compound as an active ingredient. The novel indazole derivatives exhibit excellent ABL/DDR1 inhibitory efficacy and anti-proliferative efficacy against cancer cells, specifically blood cancer cells, and inhibitory activity against ABL T315I point mutations, thus being useful for the prevention, alleviation or treatment of cancer, specifically blood cancer, especially chronic myelogenous leukemia.

DISUBSTITUTED ALKYNE DERIVATIVES

The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.