77133-35-8 Usage
Description
1-O-HEXADECYL-2-O-ACETYL-SN-GLYCEROL, also known as C16-02:0 DG or Hexadecyl acetyl glycerol (HAG), is a lipid compound with a hexadecyl group at the first carbon and an acetyl group at the second carbon of the glycerol backbone. It plays a crucial role in modulating lipid metabolism and has potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
1-O-HEXADECYL-2-O-ACETYL-SN-GLYCEROL is used as a preventive agent for the formation of 1-O-acyl-NAS (acylated plasmalogen species), which are associated with various pathological conditions, including neurodegenerative diseases and ischemic injuries. By inhibiting the formation of 1-O-acyl-NAS, HAG can potentially protect cells from damage and contribute to the development of therapeutic strategies for these conditions.
Used in Cosmetic Industry:
1-O-HEXADECYL-2-O-ACETYL-SN-GLYCEROL is used as an ingredient in cosmetic formulations for its emollient and skin conditioning properties. Its lipid structure allows it to penetrate the skin and provide moisturization, improving skin texture and appearance.
Used in Food Industry:
1-O-HEXADECYL-2-O-ACETYL-SN-GLYCEROL can be used as an ingredient in food products to improve texture and stability. Its lipid nature allows it to act as an emulsifier, helping to maintain the consistency and shelf life of various food products.
Biochem/physiol Actions
C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) is a diacylglycerol (DAG) antagonist with a potential to inhibit protein kinase C (PKC) activity. It also has an ability to inhibit growth of human promyelocytic leukemia cell line HL-60. HAG serves as a precursor in the biosynthesis of platelet-activating factor.
Check Digit Verification of cas no
The CAS Registry Mumber 77133-35-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,3 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77133-35:
(7*7)+(6*7)+(5*1)+(4*3)+(3*3)+(2*3)+(1*5)=128
128 % 10 = 8
So 77133-35-8 is a valid CAS Registry Number.
77133-35-8Relevant articles and documents
A direct transformation of O-silyl groups into O-trichloroacetates. A novel synthetic approach to protein kinase C ligands: 1-Oleoyl-2-acetyl- and 1-hexadecyl-2-acetyl-sn-glycerols
Stamatov, Stephan D.,Kullberg, Martin,Stawinski, Jacek
, p. 6855 - 6859 (2005)
A fluoride ion-promoted direct esterification of tert-butyldimethylsilyl- (TBDMS), or triisopropylsilyl (TIPS)-protected glycerol derivatives by means of trichloroacetic anhydride (TCAA), followed by removal of the trichloroacetyl transient protection, provides a new, efficient entry to stereochemically pure 1-oleoyl-2-acetyl- and 1-O-hexadecyl-2-acetyl-sn-glycerols.
Novel chemo-enzymatic synthesis of optically active platelet activating factor
Kumar,Bhakuni
, p. 3463 - 3466 (2007/10/02)
This paper describes an enantioselective enzymatic synthesis of biologically active platelet activating factor (PAF) starting from chloropyruvic acid.
Synthesis of 1-O-alkyl-2-O-acetyl-Sn-3-glyceryl-3-phosphoryl choline the enantiomer of platelet activating factor (PAF)
Kumar,Shanker
, p. 1763 - 1768 (2007/10/02)
A novel sterospecific synthesis of biologically active ether-phospholipids (PAF) is reported, involving chemoenzymatic approach.
