771510-32-8

Basic information

• Product Name: 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine
• Synonyms: 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine;5,7-Dichloro-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidine
• CAS NO: 771510-32-8
• Molecular Formula: C₉H₉Cl₂N₃
• Molecular Weight: 230
• EINECS: 200-110-4
• Mol File: 771510-32-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Density: 1.46
• Storage Temp.: 2-8°C
• PKA: -1.45±0.30(Predicted)
• CAS DataBase Reference: 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine(771510-32-8)
• EPA Substance Registry System: 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine(771510-32-8)

Safety Data

• Hazardous Substances Data: 771510-32-8(Hazardous Substances Data)

Usage

General Description

5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine is a chemical compound with the molecular formula C8H8Cl2N4. It is a pyrazolopyrimidine derivative, which is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. The compound is known for its potent biological activities, including anti-inflammatory, antibacterial, and antitumor properties. It acts as an inhibitor of multiple kinases, making it a potential target for the treatment of various diseases such as cancer and inflammatory disorders. Due to its versatile pharmacological properties, 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine is widely studied in medicinal chemistry and drug discovery for the development of new therapeutic agents.

Upstream product

• 151521-49-2 4-isopropyl-1H-pyrazol-3-amine 
• 151521-49-2 4-isopropyl-1 H-pyrazol-5-amine 
• 771510-15-7 2-formyl-3-methylbutanenitrile 
• 625-28-5 Isovaleronitrile 
• 771510-25-9 3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 1092443-98-5 benzyl-(5-chloro-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)-amine 
• 1092444-36-4 N-(2-fluorobenzyl)-5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-amine 
• 1092444-33-1 benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester 
• 1256288-44-4 tert-butyl benzyl(5-((6-((tert-butoxycarbonyl)amino)hexyl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate 
• 1092444-48-8 tert-butyl (R)-benzyl-{5-[1-(tert-butyl-dimethylsilyloxy)-9-(6-fluoropyridin-3-yl)-non-2-ylamino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-7-yl}carbamate 
• 1092444-38-6 [(R)-6-{7-[tert-butoxycarbonyl-(2-fluoro-benzyl)-amino]-3-isopropyl-pyrazolo[1,5-a]pyrimidin-5-ylamino}-7-(tert-butyl-dimethyl-silanyloxy)-heptyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

CDK inhibitor based on organic arsine as well as preparation method and application of CDK inhibitor

The invention provides a CDK inhibitor based on organic arsine as well as a preparation method and application of the CDK inhibitor. Specifically, the invention providese compounds of Formula I, or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, hydrates or solvates thereof; and the invention also discloses a preparation method and application thereof. Definitions of allgroups in the formula are shown in the specification.

PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITOR OF CYCLIN DEPENDENT KINASE

The present invention relates to pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[l,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

Synthesis method of pyrazolo[1,5-A]pyrimidine heterocyclic compound and derivative

The invention relates to a pynthesis method of pyrazolo[1,5-A]pyrimidine heterocyclic compounds and derivatives. The synthesis method comprises the following steps: (1) preparing N-boc-1,4-cyclohexanediamine; (2), preparing 2-formyl-3-methyl-butyronitrile; (3), preparing 4-isopropyl-1H-pyrazol-5-amine; (4) preparing 3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol; (5), preparing 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine; (6) utilizing 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyridine to prepare 5,7-dibromo-3-isopropylpyrazolo[1,5-a]pyrimidine; (7) preparing 4-(5-bromo-3-isopropylpyrazolo[1,5-a]pyrimidin-7-ylamino)-N,N-dimethylbenzenesulfonamide; and (8) preparing 4-(5-(4-(1,1-dimethylethoxy)carbonyl)-aminocyclohexylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-ylamino)-N,N-dimethylbenzenesulfonamide. According to the method, the reaction process is optimized, the reaction steps are simplified, and the reaction conversion rate and the product yield are improved.