Welcome to LookChem.com Sign In|Join Free

CAS

  • or

771579-27-2

Post Buying Request

771579-27-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

771579-27-2 Usage

General Description

2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) is a chemical compound with the molecular formula C9H11N3O. It is a derivative of pyridine and is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active compounds. This chemical is known for its antimicrobial, antifungal, and anti-inflammatory properties. It may also have potential applications in the development of new therapeutic agents for the treatment of various diseases and conditions. Additionally, it is important to handle this chemical with caution as it may pose health risks if not used properly and in accordance with safety regulations.

Check Digit Verification of cas no

The CAS Registry Mumber 771579-27-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,1,5,7 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 771579-27:
(8*7)+(7*7)+(6*1)+(5*5)+(4*7)+(3*9)+(2*2)+(1*7)=202
202 % 10 = 2
So 771579-27-2 is a valid CAS Registry Number.

771579-27-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(aminomethyl)-4,6-dimethyl-1H-pyridin-2-one

1.2 Other means of identification

Product number -
Other names HMS1741L20

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:771579-27-2 SDS

771579-27-2Downstream Products

771579-27-2Relevant articles and documents

Small molecule compound based on EZH2 protein degradation, and application thereof

-

Paragraph 0031-0034; 0040, (2021/08/07)

The invention discloses a series of small molecule compounds capable of selectively degrading EZH2 protein, and application thereof. The compounds can be prepared into proper pharmaceutical dosage forms for EZH2-mediated related tumor treatment.

Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma

Tu, Yalin,Sun, Yameng,Qiao, Shuang,Luo, Yao,Liu, Panpan,Jiang, Zhong-Xing,Hu, Yumin,Wang, Zifeng,Huang, Peng,Wen, Shijun

, p. 10167 - 10184 (2021/07/26)

Traditional EZH2 inhibitors are developed to suppress the enzymatic methylation activity, and they may have therapeutic limitations due to the nonenzymatic functions of EZH2 in cancer development. Here, we report proteolysis-target chimera (PROTAC)-based EZH2 degraders to target the whole EZH2 in lymphoma. Two series of EZH2 degraders were designed and synthesized to hijack E3 ligase systems containing either von Hippel-Lindau (VHL) or cereblon (CRBN), and some VHL-based compounds were able to mediate EZH2 degradation. Two best degraders, YM181 and YM281, induced robust cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphomas, outperforming a clinically used EZH2 inhibitor EPZ6438 (tazemetostat) that was only effective against DLBCL. The EZH2 degraders displayed promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells. Our study demonstrates that EZH2 degraders have better therapeutic activity than EZH2 inhibitors, which may provide a potential anticancer strategy to treat lymphoma.

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

-

Paragraph 0150-0152, (2020/08/30)

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 771579-27-2