77165-71-0

Basic information

• Product Name: 4-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-1,2-diphenylpyrazolidine-3,5-dione
• Synonyms: 3,5-Pyrazolidinedione, 4-(4-hydroxy-3-methyl-2-butenyl)-1,2-diphenyl-
• CAS NO: 77165-71-0
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.3844
• Mol File: 77165-71-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 488.3°C at 760 mmHg
• Flash Point: 249.1°C
• Density: 1.244g/cm³
• Vapor Pressure: 2.38E-10mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 4-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-1,2-diphenylpyrazolidine-3,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-1,2-diphenylpyrazolidine-3,5-dione(77165-71-0)
• EPA Substance Registry System: 4-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-1,2-diphenylpyrazolidine-3,5-dione(77165-71-0)

Safety Data

• Hazardous Substances Data: 77165-71-0(Hazardous Substances Data)

Upstream product

• 62393-10-6 (Z)-1-acetoxy-2-methyl-4-chloro-but-2-ene 
• 52395-26-3 sodium salt of 1,2-diphenyl-3,5-dioxopyrazolidine 
• 83094-60-4 (Z)-4-(3-acetoxymethyl-but-2-enyl)-1,2-diphenyl-3,5-pyrazolidinedione 
• 73773-97-4 (Z)-4-(3-carbethoxy-but-2-enyl)-1,2-diphenyl-3,5-pyrazolidinedione 
• 30748-29-9 feprazone 
• 73773-96-3 (E)-4-(3-acetoxy-but-2-enyl)-1,2-diphenyl-3,5-pyrazolidinedione 
• 73774-12-6 1,2,4,5-tetrahydro-1,2-diphenyl-3H-5-hydroxyfuro<2,3-c>pyrazol-3-one 
• 73774-10-4 2-[1,3]dioxolan-2-ylmethylmalonic acid diethyl ester 
• 2652-77-9 1,2-diphenylpyrazolidine-3,5-dione 
• 62393-11-7 1-acetoxy-4-chloro-2-methyl-2-butene 
• 73773-90-7 4-(2-ethylenedioxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione 
• 83113-49-9 (Z)-1-acetoxy-2-methyl-4-(N,N-di-n-butylamino)-but-2-ene 

Relevant articles and documents

The influence of aluminium hydroxide on the bioavailability of feprazone. Single dose study

The influence of aluminium hydroxide (given as a suspension, Aludrox) on the oral bioavailability of feprazone was tested. The degree and speed of absorption of feprazone from capsules (400 mg feprazone as a single dose; 8 volunteers) was investigated by determining plasma levels of feprazone and one of its metabolites using an HPLC method. No statistically significant change in feprazone kinetics caused by the antacid was evident. C(max) (x ± SEM) decreased from 40.6 ± 2.9 to 36.25 ± 1.4 μg/ml; the mean area under the plasma level time curve was somewhat higher after additional administration of aluminium hydroxide (n.s.).

THE ACETATE OF (Z)-4-CHLORO-2-METHYL-2-BUTEN-1-OL. STEREOSELECTIVE WITTIG SYNTHESIS OF A NEW HEMITERPENOID SYNTHON

a synthetic method for the preparation of the acetate of (Z)-4-chloro-2-methyl-2-buten-1-ol, a precursor of the (Z)-hydroxy prenyl synthon is described.The use of such synthon in the preparation of a metabolite of aprenyl-containing substance is also illustrated.