77180-98-4

Basic information

• Product Name: 1-(2-deoxy-3,5-di-O-benzoyl-β-L-erythro-pentofuranosyl)-5-fluorouracil
• Synonyms: 1-(2-deoxy-3,5-di-O-benzoyl-β-L-erythro-pentofuranosyl)-5-fluorouracil
• CAS NO: 77180-98-4
• Molecular Weight: 454.411
• Mol File: 77180-98-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2-deoxy-3,5-di-O-benzoyl-β-L-erythro-pentofuranosyl)-5-fluorouracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-deoxy-3,5-di-O-benzoyl-β-L-erythro-pentofuranosyl)-5-fluorouracil(77180-98-4)
• EPA Substance Registry System: 1-(2-deoxy-3,5-di-O-benzoyl-β-L-erythro-pentofuranosyl)-5-fluorouracil(77180-98-4)

Safety Data

• Hazardous Substances Data: 77180-98-4(Hazardous Substances Data)

Upstream product

• 41545-90-8 1-(O³,O⁵-dibenzoyl-α-L-erythro-2-deoxy-pentofuranosyl)-1H-pyrimidine-2,4-dione 
• 51-21-8 5-fluorouracil 
• 51785-70-7 methyl 3,5-di-O-benzoyl-2-deoxy-L-erythro-pentofuranoside 
• 265988-67-8 1-(3,5-di-O-benzoyl-β-L-xylofuranosyl)-5-fluorouracil 
• 77180-89-3 1-(2-deoxy-3,5-di-O-benzoyl-β-L-threo-pentofuranosyl)-5-fluorouracil 
• 169527-98-4 1-(2-deoxy-β-L-threo-pentofuranosyl)-5-fluorouracil 
• 65-85-0 benzoic acid 
• 374107-75-2 1-(2-deoxy-5-O-benzoyl-β-L-threo-pentofuranosyl)-5-fluorouracil 
• 17242-85-2 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine 
• 31615-99-3 3',5'-dibenzoyl-2'-deoxy-β-L-uridine 
• 265988-66-7 1-(2-O-acetyl-3,5-di-O-benzoyl-β-L-xylofuranosyl)-5-fluorouracil 

Downstream Products

• 181785-84-2 elvucitabine 
• 725259-06-3 C₂₃H₁₉FN₂O₆S 

Relevant articles and documents

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-β-L-cytidine (β- L-d4C) and 2',3'-dideoxy-2'-3'-didehydro-β-L-5-fluorocytidine (β-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro

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Stereospecific synthesis and biological evaluations of β-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine

In the search for new chemotherapeutic agents, we have focused our work on the synthesis and the study of several unnatural β-L-nucleoside analogues. In this paper, we report on the synthesis of β-L-pentofuranonucleosides (and their 2′-deoxy derivatives) of 5-fluorouracil and their inhibitory effects on the proliferation of several murine and human tumor cells. The corresponding 5-fluorocytosine derivatives were also synthesized and their anti-HIV and anti-HBV activities have been evaluated.