772-18-9

Basic information

• Product Name: N-Ethyl 4-fluorobenzamide
• Synonyms: N-Ethyl 4-fluorobenzamide;BenzaMide, N-ethyl-4-fluoro-
• CAS NO: 772-18-9
• Molecular Formula: C₉H₁₀FNO
• Molecular Weight: 167.1802032
• Mol File: 772-18-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 289.3 °C at 760 mmHg
• Flash Point: 128.8 °C
• Appearance: /
• Density: 1.11 g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.89±0.46(Predicted)
• CAS DataBase Reference: N-Ethyl 4-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyl 4-fluorobenzamide(772-18-9)
• EPA Substance Registry System: N-Ethyl 4-fluorobenzamide(772-18-9)

Safety Data

• Hazardous Substances Data: 772-18-9(Hazardous Substances Data)

Usage

General Description

N-Ethyl 4-fluorobenzamide is a chemical compound with the molecular formula C9H10FNO. It is a derivative of benzamide, with an ethyl group and a fluorine atom attached to the benzene ring. N-Ethyl 4-fluorobenzamide is commonly used in pharmaceutical and research applications as a building block for the synthesis of various organic compounds. It may also have potential uses in the development of new drugs or treatments due to its benzamide structure, which is known to interact with biological systems. N-Ethyl 4-fluorobenzamide is a white crystalline solid with a melting point of around 99-100°C and it is important to handle it with care as it may cause skin and eye irritation.

Upstream product

• 557-66-4 ethanamine hydrochloride 
• 403-43-0 4-fluorobenzoyl chloride 
• 456-22-4 4-Fluorobenzoic acid 
• 75-04-7 ethylamine 
• 328393-70-0 1-(4-fluorophenyl)propan-1-one oxime 
• 459-56-3 4-fluorobenzylic alcohol 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1246083-88-4 N-ethyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1246084-20-7 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethylbenzamide 
• 1246083-27-1 N-ethyl-4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1018269-27-6 N-ethyl-4-(piperazin-1-yl)benzamide 
• 74554-78-2 N-acetyl-4-fluorobenzamide 
• 459-56-3 4-fluorobenzylic alcohol 
• 162401-03-8 N-(4-fluorobenzyl)ethanamine 

Relevant articles and documents

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.

Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS

Compounds of the following formula are provided for use with PARP: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds, methods and intermediates useful fo