7724-48-3

Basic information

• Product Name: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole
• Synonyms: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole;1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-(7CI,8CI,9CI);1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-;2-a]benzimidazole, 2,3-dihydro-1H-Pyrrolo[1;2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole
• CAS NO: 7724-48-3
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.1998
• EINECS: 231-770-8
• Product Categories: BENZIMIDAZOLE
• Mol File: 7724-48-3.mol
• Article Data: 34

Chemical Properties

• Melting Point: 115 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 341.9 °C at 760 mmHg
• Flash Point: 160.6 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.705
• PKA: 5.87±0.20(Predicted)
• CAS DataBase Reference: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole(7724-48-3)
• EPA Substance Registry System: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole(7724-48-3)

Safety Data

• Hazardous Substances Data: 7724-48-3(Hazardous Substances Data)

Usage

General Description

2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole is a heterocyclic compound with a fused pyrrole and benzimidazole ring system. It is used as a building block in the synthesis of various pharmaceuticals and organic compounds. This chemical possesses potential pharmacological activities, and is being studied for its potential use in the treatment of various diseases. Its unique structure and properties make it a valuable intermediate in organic synthesis and medicinal chemistry. Additionally, it has shown promise as a potential lead compound in drug development due to its diverse biological activities. Overall, 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole is an important chemical with potential applications in pharmaceutical research and drug discovery.

InChI:InChI=1/C10H10N2/c1-2-5-9-8(4-1)11-10-6-3-7-12(9)10/h1-2,4-5H,3,6-7H2

Upstream product

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• 64352-78-9 trans-dimeric 2-iodonitrosobenzene 
• 19519-75-6 1-bromo-2-nitrosobenzene 
• 932-33-2 o-Chloronitrosobenzene 

Downstream Products

• 21627-58-7 2-(pyrrolidin-1-yl)-phenylamine 
• 39161-58-5 1,2,3,4,5,6-hexahydro-benzo[b][1,4]diazocine 

Relevant articles and documents

Electrochemical Synthesis of Benzo[ d]imidazole via Intramolecular C(sp3)-H Amination

An electrochemical dehydrogenative amination for the synthesis of benzimidazoles was developed. This electrosynthesis method could address the limitations of the C(sp3)-H intramolecular amination synthesis reaction and provide novel access to obtain 1,2-disubstituted benzimidazoles without transition metals and oxidants. Under undivided electrolytic conditions, various benzimidazole derivatives could be synthesized, exhibiting functional group tolerance.

Synthesis of rutaecarpine alkaloids: Via an electrochemical cross dehydrogenation coupling reaction

Substrates are directly oxidized at the anode without using any metal catalyst and oxidant to obtain a series of nitrogen heterocyclic compounds, including benzimidazoles and quinolinones. These compounds are highly tolerant to various functional groups and heterocycle-containing substrates. In addition, natural alkaloids, such as rutaecarpine and deoxyvasicinone, can be synthesized by this method.

BENZIMIDAZOLE COMPOUND AND SYNTHESIS METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a novel benzimidazole compound having tetracyclic condensed ring and a synthesis method thereof. SOLUTION: A benzimidazole compound is represented by the formula (I). A method for synthesizing the benzimidazole compound represented by the formula (I) includes the step of reacting ortho-phenylene diamine and a lactone compound and further reacting the resulting benzimidazole compound with the lactone compound. In the formula, R1 and R4 are each independently H, a methyl group or an ethyl group excluding that two of R4 are ethyl groups or methyl groups at same time, R2 and R3 are each independently H or a methyl group, m and n are integers of 1 to 2 and n is 1 when m is 2. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT