7726-08-1

Basic information

• Product Name: N-Caprinoylethanolamide
• Synonyms: N-(2-Hydroxyethyl)capric acid amide;N-(2-Hydroxyethyl)capric amide;N-(2-Hydroxyethyl)caprinamide;N-(2-Hydroxyethyl)decanamide;N-Caprinoylethanolamide
• CAS NO: 7726-08-1
• Molecular Formula: C₁₂H₂₅NO₂
• Molecular Weight: 215.33
• Mol File: 7726-08-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 78-80 °C(Solv: water (7732-18-5))
• Boiling Point: 384.9±25.0 °C(Predicted)
• Appearance: /
• Density: 0.935±0.06 g/cm3(Predicted)
• PKA: 14.49±0.10(Predicted)
• CAS DataBase Reference: N-Caprinoylethanolamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Caprinoylethanolamide(7726-08-1)
• EPA Substance Registry System: N-Caprinoylethanolamide(7726-08-1)

Safety Data

• Hazardous Substances Data: 7726-08-1(Hazardous Substances Data)

Upstream product

• 110-38-3 decanoic acid ethyl ester 
• 141-43-5 ethanolamine 
• 112-13-0 n-decanoyl chloride 
• 334-48-5 1-decanoic acid 

Downstream Products

• 7596-88-5 N-dodecanoylglycine 
• 14246-55-0 N-myristoylglycine 
• 2441-41-0 N-palmitoyl glycine 
• 6333-54-6 N-stearoylglycine 
• 14305-32-9 N-n-decanoylglycine 
• 14246-53-8 N-(1-oxooctyl)glycine 

Relevant articles and documents

Synthesis, antimicrobial evaluation, QSAR and in silico ADMET studies of decanoic acid derivatives

Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well as against fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were developed using multiple linear regression and cross validated by leave one out (LOO) approach. QSAR studies indicated that activity against Gram positive bacteria was governed by lipophilicity of the compounds while topological steric nature of the molecule was deciding factor for antifungal activity. Further, in silico ADMET studies showed that compounds CD12, 19, 20 and 23 could be explored further for other activities.

N-acylation of ethanolamine using lipase: A chemoselective catalyst

The N-acylation of ethanolamine (2) with various fatty acids 1a-d and esters of fatty acids 1e-h using Candida antarctica B lipase (Novozym 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed. Microwave assisted solution phase, solid supported and conventional methods were investigated and results were compared. There is a synergy between the enzyme catalysis and microwave irradiation.

USE OF CERTAIN N-ACYLETHANOLAMINES TO ACHIEVE ETHYLENE- AND CYTOKININ-LIKE EFFECTS IN PLANTS AND FUNGI

N-acylethanolamines (NAEs) that can deliver an ethylene- or cytokinin-like effects to a plant, plant part or fungus are disclosed. Also disclosed are methods of using the NAES.