77287-11-7Relevant articles and documents
Highly Diastereoselective Cycloadditions via Chelation Control: Asymmetric Synthesis of β-Lactones
Zemribo, Ronald,Romo, Daniel
, p. 4159 - 4162 (1995)
Chelation controlled cycloadditions of trimethylsilylketene to chiral α- and β-benzyloxyaldehydes followed by desilylation provides a highly diastereoselective route to functionalized β-lactones.Several Lewis acids were examined and MgBr2*Et2O was found to give the highest diastereoselectivities and yields.
BENZAMIDE COMPOUNDS AS ROR GAMMA MODULATORS
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Page/Page column 41, (2017/12/16)
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4, R5, n and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
Total synthesis and biological activity of dolastatin 16
Casalme, Loida O.,Yamauchi, Arisa,Sato, Akinori,Petitbois, Julie G.,Nogata, Yasuyuki,Yoshimura, Erina,Okino, Tatsufumi,Umezawa, Taiki,Matsuda, Fuyuhiko
supporting information, p. 1140 - 1150 (2017/02/10)
The total synthesis of dolastatin 16, a macrocyclic depsipeptide first isolated from the sea hare Dolabella auricularia as a potential antineoplastic metabolite by Pettit et al., was achieved in a convergent manner. Dolastatin 16 was reported by Tan to ex
