77300-48-2

Basic information

• Product Name: DL-NORLEUCINE METHYL ESTER HYDROCHLORIDE
• Synonyms: Methyl 2-aminohexanoate hydrochloride;DL-Nle-OMe·HCl;H-DL-NLE-OME HCL;DL-2-AMINOHEXANOIC ACID-METHYL ESTER HCL;DL-NORLEUCINE METHYL ESTER HYDROCHLORIDE;DL-NORLEUCINE-OME HCL;dl-norleucine methyl ester hcl
• CAS NO: 77300-48-2
• Molecular Formula: C₇H₁₅NO₂*ClH
• Molecular Weight: 181.66
• Product Categories: Amino Acids;I - Z;Modified Amino Acids
• Mol File: 77300-48-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 117-119℃ (methanol water )
• Boiling Point: 175.4 °C at 760 mmHg
• Flash Point: 48.4 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DL-NORLEUCINE METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-NORLEUCINE METHYL ESTER HYDROCHLORIDE(77300-48-2)
• EPA Substance Registry System: DL-NORLEUCINE METHYL ESTER HYDROCHLORIDE(77300-48-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 77300-48-2(Hazardous Substances Data)

Usage

Uses

DL-Norleucine methyl ester, HCl

Biochem/physiol Actions

DL-Norleucine methyl ester hydrochloride is a neurotransmitter commonly used as an internal standard.

Upstream product

• 67-56-1 methanol 
• 616-06-8 2-amino-hexanoic acid 
• 327-57-1 L-Norleucine 
• 203855-78-1 methyl 2-((diphenylmethylene)amino)hexanoate 
• 1279107-64-0 methyl 2-benzylideneaminohexanoate 

Downstream Products

• 127750-58-7 N-cinnamoyl-D,L-norleucine methyl ester 
• 203855-78-1 methyl 2-((diphenylmethylene)amino)hexanoate 
• 1609166-30-4 rac-benzyl (2-hydroxy-2-methylheptan-3-yl)carbamate 
• 34337-16-1 N-(4-methoxybenzoyl)-DL-norleucine 
• 1609081-95-9 rac-methyl N-({8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)norleucinate 
• 134306-35-7 rac-methyl N-[(benzyloxy)carbonyl]norleucinate 
• 1055912-69-0 C₁₅H₂₁NO₄ 
• 1279107-64-0 methyl 2-benzylideneaminohexanoate 
• 134915-97-2 (S)-3-({2-[1-(2-Amino-acetylamino)-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carbonyl}-amino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid 
• 134915-96-1 (S)-3-({2-[1-Amino-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carbonyl}-amino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid 
• 134915-94-9 2-[1-Benzyloxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carboxylic acid methyl ester 
• 296282-03-6 2-[2-(2-amino-benzoylamino)-benzoylamino]-hexanoic acid methyl ester 

Relevant articles and documents

Regiodivergent Enantioselective γ-Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α-Amino Acids and N,O-Acetal Derivatives

Phosphine-catalyzed regiodivergent enantioselective C-2- and C-4-selective γ-additions of oxazolones to 2,3-butadienoates have been developed. The C-4-selective γ-addition of oxazolones occurred in a highly enantioselective manner when 2-aryl-4-alkyloxazol-5-(4H)-ones were employed as pronucleophiles. With the employment of 2-alkyl-4-aryloxazol-5-(4H)-ones as the donor, C-2-selective γ-addition of oxazolones took place in a highly enantioselective manner. The C-4-selective adducts provided rapid access to optically enriched α,α-disubstituted α-amino acid derivatives, and the C-2-selective products led to facile synthesis of chiral N,O-acetals and γ-lactols. Theoretical studies via DFT calculations suggested that the origin of the observed regioselectivity was due to the distortion energy that resulted from the interaction between the nucleophilic oxazolide and the electrophilic phosphonium intermediate.

Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes

Cascade reaction sequences incorporating N-heterocyclic carbene-based organocatalysis have been developed that allow the direct preparation of a range of (±)-4-phenoxycarbonylazlactones in good isolated yields (66-84%) from the corresponding N-p-anisoyl amino acids. The Royal Society of Chemistry.

New 2-(2'-phenyl-9'-benzyl-8'-azapurin-6'-ylamino)-carboxylic acid methylesters as ligands for A1 adenosine receptors.

Synthesis of a series of new 2-phenyl-9-benzyl-8-azaadenines bearing on N6 an alkyl or aralkyl chain having a carbonyloxymethyl group on the carbon bound to N6 were reported. The ester group could assure to the molecule a better water-solubility than the 8-azaadenines 2, 6 and 9 substituted with lipophilic groups synthesised in the past. Compounds synthesised demonstrated only little capability of binding A1 adenosine receptors.