773099-17-5

Basic information

• Product Name: 2-broMo-1H-iMidazole-4,5-dicarboxylic acid
• Synonyms: 2-broMo-1H-iMidazole-4,5-dicarboxylic acid
• CAS NO: 773099-17-5
• Molecular Formula: C₅H₃BrN₂O₄
• Molecular Weight: 234.99232
• EINECS: 200-258-5
• Mol File: 773099-17-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-broMo-1H-iMidazole-4,5-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-1H-iMidazole-4,5-dicarboxylic acid(773099-17-5)
• EPA Substance Registry System: 2-broMo-1H-iMidazole-4,5-dicarboxylic acid(773099-17-5)

Safety Data

• Hazardous Substances Data: 773099-17-5(Hazardous Substances Data)

Usage

Description

2-Bromo-1H-imidazole-4,5-dicarboxylic acid, also known as 4,5-dibromohydantoin, is a chemical compound with the molecular formula C5H4Br2N2O4. It is a white to off-white solid that is soluble in water and is commonly used in the synthesis of pharmaceuticals, agrochemicals, and in chemical research and development. It also serves as a reagent in organic synthesis and a building block for the preparation of various heterocyclic compounds, making it a valuable intermediate in the production of a range of important chemical compounds.

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-Bromo-1H-imidazole-4,5-dicarboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Chemical Research and Development:
As a versatile chemical compound, 2-Bromo-1H-imidazole-4,5-dicarboxylic acid is utilized in chemical research and development for the exploration of new chemical reactions and the creation of novel compounds.
Used as a Reagent in Organic Synthesis:
2-Bromo-1H-imidazole-4,5-dicarboxylic acid serves as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the synthesis of complex organic molecules.
Used in the Preparation of Heterocyclic Compounds:
2-Bromo-1H-imidazole-4,5-dicarboxylic acid is used as a building block for the preparation of various heterocyclic compounds, which are important in the fields of pharmaceuticals, materials science, and other chemical applications.

Upstream product

• 129756-78-1 diethyl 2-bromo-1H-imidazole-4,5-dicarboxylate 
• 570-22-9 4,5-imidazoledicarboxylic acid 
• 1080-79-1 imidazole 4,5-dicarboxylic acid diethyl ester 

Downstream Products

• 129756-80-5 [5-¹⁵N]-5-((4-bromophenyl)azo)-2-bromo-4-imidazolecarboxylic acid 

Relevant articles and documents

15N-Multilabeled Adenine and Guanine Nucleosides. Syntheses of [1,3,NH2-15N3]- and [2-13C-1,3,NH2-15N3]-Labeled Adenosine, Guanosine, 2′-Deoxyadenosine, and 2′-Deoxyguanosine

We report a high-yield route to the following specifically 15N- and 13C-multilabeled nucleosides: [1,3,NH2-15N3]- and [2-13C-1,3,NH2-15N3]-adenosine; [1,3,NH2-15N3]- and [2-13C-1,3,NH2-15N3]-guanosine; [1,3,NH2-15N3]- and [2-13C-1,3,NH2-15N 3]-2′-deoxyadenosine; [1,3,NH2-15N3]- and [2-13C-1,3,-NH2-15N 3]-2′-deoxyguanosine. In each set, the 13C2 atom functions as a "tag" that allows the 15N1 and 15N3 atoms to be unambiguously differentiated from the untagged versions in 15N NMR of RNA or DNA fragments. The key intermediate of this synthetic strategy for both the adenine and guanine nucleosides is [NH2,CONH2-15N 2]-5-amino-4-iimdazolecarboxamide. The [2-13C]-label is added through a ring closure using [13C]-sodium ethyl xanthate (NaS13CSOEt). Enzymatic transglycosylation of either multilabeled 6-chloropurine or multilabeled 2-mercaptohypoxanthine and a final reaction with 15NH3 give the adenine and guanine nucleosides. This is the first report of a [3-15N]-labeled guanine nucleoside.