773137-52-3

Basic information

• Product Name: ethyl 1-methyl-2-phenyl-1H-indole-3-carboxylate
• Synonyms: ethyl 1-methyl-2-phenyl-1H-indole-3-carboxylate
• CAS NO: 773137-52-3
• Molecular Weight: 279.338
• Mol File: 773137-52-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 1-methyl-2-phenyl-1H-indole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-methyl-2-phenyl-1H-indole-3-carboxylate(773137-52-3)
• EPA Substance Registry System: ethyl 1-methyl-2-phenyl-1H-indole-3-carboxylate(773137-52-3)

Safety Data

• Hazardous Substances Data: 773137-52-3(Hazardous Substances Data)

Upstream product

• 618-40-6 1-Methyl-1-phenylhydrazine 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 3558-24-5 1-methyl-2-phenyl-1H-indole 
• 541-41-3 chloroformic acid ethyl ester 
• 614-00-6 N-methyl-N-nitrosoaniline 
• 28383-65-5 ethyl 2-diazo-3-oxo-3-phenylpropanoate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 100-61-8 N-methylaniline 

Downstream Products

• 26821-93-2 (1-methyl-2-phenyl-1H-indol-3-yl)(phenyl)methanone 
• 59050-41-8 2-phenyl-1-methylindole-3-carboxylic acid 

Relevant articles and documents

A convenient and general method for the synthesis of indole-2,3- dicarboxylates and 2-arylindole-3-carboxylates

A transition-metal-free, simple and efficient one-pot method for the synthesis of indole-2,3-dicarboxylates and 2-aryl-indole-3-carboxylates is described. The corresponding products are obtained by a domino hydroamination/Fischer indole cyclization in goo

C-H Activation-Based Traceless Synthesis via Electrophilic Removal of a Directing Group. Rhodium(III)-Catalyzed Entry into Indoles from N-Nitroso and α-Diazo-β-keto Compounds

A distinct C-H activation-based traceless synthetic protocol via electrophilic removal of a directing group is reported, complementing the currently exclusively used nucleophilic strategy. Rh(III)-catalyzed, N-nitroso-directed C-H activation allows the development of a traceless, atom- and step-economic, cascade approach for the synthesis of indole skeletons, starting from readily available N-nitroso and α-diazo-β-keto compounds. Importantly, the cyclization/denitrosation reaction represents a hitherto unobserved reactivity pattern for the N-nitroso group.