7732-36-7

Basic information

• Product Name: 2-[(2-amino-5-methoxyphenyl)dithio]-4-methoxyaniline
• Synonyms: 2-[(2-amino-5-methoxyphenyl)dithio]-4-methoxyaniline;[2-(2-amino-5-methoxy-phenyl)disulfanyl-4-methoxy-phenyl]amine;2-(2-amino-5-methoxy-phenyl)disulfanyl-4-methoxy-aniline;2-(2-amino-5-methoxyphenyl)disulfanyl-4-methoxyaniline
• CAS NO: 7732-36-7
• Molecular Formula: C₁₄H₁₆N₂O₂S₂
• Molecular Weight: 308.41904
• Mol File: 7732-36-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 82 °C
• Boiling Point: 469.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 3.84±0.10(Predicted)
• CAS DataBase Reference: 2-[(2-amino-5-methoxyphenyl)dithio]-4-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-amino-5-methoxyphenyl)dithio]-4-methoxyaniline(7732-36-7)
• EPA Substance Registry System: 2-[(2-amino-5-methoxyphenyl)dithio]-4-methoxyaniline(7732-36-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7732-36-7(Hazardous Substances Data)

Usage

Description

2-[(2-amino-5-methoxyphenyl)dithio]-4-methoxyaniline, also known as 2,2''-Dithiobis[4-methoxybenzenamine], is an organic compound that serves as a byproduct in the synthesis of 2-Amino-5-methoxythiophenol (A627990). This chemical reagent is utilized in the production of antibacterial benzothiazepines, which are a class of compounds with significant potential in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
2-[(2-amino-5-methoxyphenyl)dithio]-4-methoxyaniline is used as a chemical reagent for the synthesis of 2-Amino-5-methoxythiophenol (A627990), which is an essential precursor in the production of antibacterial benzothiazepines. These benzothiazepines exhibit potent antibacterial properties, making them valuable in the development of new antibiotics to combat drug-resistant bacterial infections.

Upstream product

• 10205-69-3 6-methoxy-2-phenylbenzothiazole 
• 35350-40-4 bis-(5-methoxy-2-nitro-phenyl)-disulfide 
• 7732-18-5 water 
• 6274-29-9 2-amino-5-methoxy-thiophenol 
• 90-04-0 2-methoxy-phenylamine 
• 2941-69-7 5-methoxy-2-methylbenzo[d]thiazole 
• 104-94-9 4-methoxy-aniline 
• 28987-59-9 3-chloro-4-nitroanisole 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 2942-13-4 6-methoxy-1,3-benzothiazole 
• 71368-35-9 6-methoxybenzo[d]thiazole-2-carbothioamide 

Downstream Products

• 76273-50-2 (7-Methoxy-3-phenyl-4H-benzo[1,4]thiazin-2-yl)-phenyl-methanone 
• 22726-30-3 7-methoxy-2H-benzo[b][1,4]thiazin-3(4H)-one 
• 182619-15-4 (6-methoxybenzo[d]thiazol-2-yl)(4-methoxyphenyl)methanone 
• 40925-65-3 6-methoxybenzo[d]thiazol-2(3H)-one 
• 2182-73-2 6-methoxy-1,3-benzothiazole-2-thiol 
• 10544-50-0 sulfur 
• 43036-17-5 2-(4-aminophenyl)-6-methoxybenzothiazole 
• 10205-69-3 6-methoxy-2-phenylbenzothiazole 
• 2942-13-4 6-methoxy-1,3-benzothiazole 
• 1216935-80-6 C₁₄H₁₁NO₂S 

Relevant articles and documents

Synthesis of 2-arylbenzothiazoles via direct condensation between in situ generated 2-aminothiophenol from disulfide cleavage and carboxylic acids

In this work we describe a simple and efficient general methodology for 2-arylbenzothiazole preparation employing disulfides and carboxylic acids. The reaction is promoted by tributylphosphine that acts both in disulfide bond cleavage and as activating agent for coupling with carboxylic acids. The reaction scope was studied using bis(2-aminophenyl)disulfide and different carboxylic acids with donor/withdrawing substituents, which resulted in the desired 2-arylbenzothiazole with moderate to good yields. The method was tested with success in preparation of the amyloid probe 2-(4-aminophenyl)-6-methoxybenzothiazole that employed a substituted bis(2-aminophenyl)disulfide.

PROBES FOR IMAGING HUNTINGTIN PROTEIN

Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.

USE OF CONDENSED BENZO[B]THIAZINE DERIVATIVES AS CYTOPROTECTANTS

The present invention relates to arylthiazine compounds, metabolites, N-oxides, amides, esters,pharmaceutically acceptable salts, hydrates and solvates thereof and their use as cytoprotectants in the treatment or prophylaxis of diseases or states, either acute or chronic, involving aberrant cellular lipid peroxidation in the central nervous system or in the periphery of the body. The present invention also relates to a method for their preparation and to pharmaceutical composition comprising as an active ingredient one or more of the aforementioned compounds.