77337-76-9 Usage
Description
3-(acetylamino)propanesulphonic acid, also known as Campral, is an organosulfonic acid that is propane-1-sulfonic acid substituted by an acetylamino group at position 3. It is a pharmaceutical compound used for the treatment of alcohol dependency.
Uses
Used in Pharmaceutical Industry:
3-(acetylamino)propanesulphonic acid is used as a therapeutic agent for the treatment of alcohol dependency. It helps to reduce the craving for alcohol and supports the recovery process by managing withdrawal symptoms and preventing relapse.
Originator
Campral,Merck
Manufacturing Process
In a 4 liter flask provided with stirring means, a bromine funnel and a
thermometer, 17.5% sodium hydroxide solution and aminopropanesulfonic
acid (homotaurine) are added.
After complete dissolution, at a temperature of between 25°-40°C, acetic
anhydride are added so as not to exceed a temperature of between 30°-40°C.
The mixture is then maintained at this temperature by heating for at least 1
h.
The solution is then concentrated in vacuum, the residue is redissolved in 2.5
L of distilled water and the mixture is concentrated again. The residue is then
dissolved in 1.6 L of distilled water, filtered, then concentrated almost
completely. Drying is terminated in an oven in vacuum. A colorless crystalline
powder of 3-acetylaminopropanesulfonate of sodium (sodium Nacetylhomotaurinate)
is obtained.
The 3-acetylaminopropanesulfonic acid may be produced by treatment of 3-
acetylaminopropanesulfonate of sodium with hydrochloric acid.
In practice it is usually used as calcium salt.
Check Digit Verification of cas no
The CAS Registry Mumber 77337-76-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,3,3 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 77337-76:
(7*7)+(6*7)+(5*3)+(4*3)+(3*7)+(2*7)+(1*6)=159
159 % 10 = 9
So 77337-76-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NO4S/c1-5(7)6-3-2-4-11(8,9)10/h2-4H2,1H3,(H,6,7)(H,8,9,10)
