77361-32-1

Basic information

• Product Name: N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE
• Synonyms: N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE;N-(N’-Boc-2-ethylamine)phthalimide;[2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]carbaMic Acid 1,1-DiMethylethyl Ester;tert-Butyl (2-(1,3-dioxoisoindolin-2-yl)ethyl)carbaMate;[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-carbaMic acid tert-butyl ester
• CAS NO: 77361-32-1
• Molecular Formula: C₁₅H₁₈N₂O₄
• Molecular Weight: 290.31
• Product Categories: Aromatics;Heterocycles;Intermediates
• Mol File: 77361-32-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: Methanol
• CAS DataBase Reference: N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE(77361-32-1)
• EPA Substance Registry System: N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE(77361-32-1)

Safety Data

• Hazardous Substances Data: 77361-32-1(Hazardous Substances Data)

Usage

Description

N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE is a chemical compound that serves as an intermediate in the synthesis of various antibacterial agents, pharmaceuticals, and drug metabolites. It is characterized by its unique structure, which includes a Boc-protected amine group and an isoindole moiety.

Uses

Used in Pharmaceutical Industry:
N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE is used as an intermediate in the preparation of various pharmaceuticals for its ability to be incorporated into the molecular structures of these compounds, enhancing their therapeutic properties.
Used in Antibacterial Agents:
In the field of antibacterial agents, N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE is used as a key component in the synthesis of various compounds that exhibit potent antibacterial activity, contributing to the development of new and effective treatments against bacterial infections.
Used in Drug Metabolites:
N-1-BOC-2-(1',3'-DIHYDRO-1',3'-DIOXO-2'H-ISOINDOL-2'-YL) ETHYLAMINE is also utilized in the study and production of drug metabolites, which are the byproducts of drug metabolism in the body. Its unique structure allows for the investigation of metabolic pathways and the development of drugs with improved pharmacokinetics and reduced side effects.

Upstream product

• 85-44-9 phthalic anhydride 
• 57260-73-8 N-BOC-1,2-diaminoethane 

Downstream Products

• 886779-85-7 tert-butyl 3-cyclopropylpiperazine-1-carboxylate 
• 886779-61-9 tert-butyl 3-(tert-butyl)piperazine-1-carboxylate 
• 183742-29-2 piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 886769-95-5 tert-butyl 3-(benzo[d][1,3]dioxol-5-yl)piperazine-1-carboxylate 
• 886768-17-8 tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate 
• 1557288-14-8 tert-butyl 3-(2-chloro-4-fluorophenyl)piperazine-1-carboxylate 
• 886767-93-7 tert-butyl 3-(4-(trifluoromethyl)phenyl)piperazine-1-carboxylate 
• 121495-40-7 tert-butyl (2-(1,3-dioxoisoindolin-2-yl)ethyl)(methyl)carbamate 

Relevant articles and documents

COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOG, AT LEAST ONE IONIC SPECIES AND AN AMPHOIPHILIC COMPOUNDS CONTAINING HYDRIPHOBIC RADICALS

A composition in the form of an injectable solution includes: amylin, an amylin receptor agonist or an amylin analog; at least one ionic species; and an amphiphilic compound having a hydrophilic skeleton HB, substituted by at least one hydrophobic radical -Hy according to formula (I). A composition further is characterised in that it also has prandial insulin. In one embodiment, the composition also has GLP-1, GLP-1 analogs, and GLP-1 receptor agonists, commonly called GLP-1 RA.

Development of unsymmetrical dyads as potent noncarbohydrate-based inhibitors against human β-N-acetyl-D-hexosaminidase

Human β-N-acetyl-D-hexosaminidase has gained much attention due to its roles in several pathological processes and been considered as potential targets for disease therapy. A novel and efficient skeleton, which was an unsymmetrical dyad containing naphthalimide and methoxyphenyl moieties with an alkylamine spacer linkage as a noncarbohydrate-based inhibitor, was synthesized, and the activities were valuated against human β-N-acetyl-D- hexosaminidase. The most potent inhibitor exhibits high inhibitory activity with Ki values of 0.63 μM. The straightforward synthetic manners of these unsymmetrical dyads and understanding of the binding model could be advantageous for further structure optimization and development of new therapeutic agents for Hex-related diseases.