773873-68-0Relevant articles and documents
Synthesis and biological evaluation of indazole derivatives
Claramunt, Rosa M.,López, Concepción,López, Ana,Pérez-Medina, Carlos,Pérez-Torralba, Marta,Alkorta, Ibon,Elguero, José,Escames, Germaine,Acu?a-Castroviejo, Darío
experimental part, p. 1439 - 1447 (2011/04/24)
The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibiti
Methods of treatment with compounds having RARα receptor specific or selective activity
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, (2008/06/13)
Retinoid compounds which act specifically or selectively on RARα receptor subtypes in preference over RARβ and RARγ receptor subtypes, posses desirable pharmaceutical properties associated with retinoids, and are particularly suitable for treatment of tumors, such as acute monocytic leukemia, cervical carcinoma, myeloma, ovarian carcinomas and head and neck carcinomas, without having one or more undesirable side effects of retinoids, such as inducement of weight loss, mucocutaneous toxicity, skin irritation and teratogenecity.
Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
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, (2008/06/13)
Compounds of the formula STR1 where the symbols have the meaning defined in the specification have retinoid-like biological activity.