774165-27-4

Basic information

• Product Name: 2-AMino-4-isopropylbenzoic acid
• Synonyms: 2-AMino-4-isopropylbenzoic acid
• CAS NO: 774165-27-4
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• Mol File: 774165-27-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 322.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.161±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.09±0.10(Predicted)
• CAS DataBase Reference: 2-AMino-4-isopropylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-4-isopropylbenzoic acid(774165-27-4)
• EPA Substance Registry System: 2-AMino-4-isopropylbenzoic acid(774165-27-4)

Safety Data

• Hazardous Substances Data: 774165-27-4(Hazardous Substances Data)

Usage

Chemical compound

2-Amino-4-isopropylbenzoic acid

Structure

Contains a benzene ring with an isopropyl group attached to the 4-position and an amino group at the 2-position

Uses

Used in organic synthesis and pharmaceutical research

Function

Building block for the production of various compounds, including potential medications

Properties

Useful in the development of drugs targeting specific biological pathways

Intermediate

Used in the preparation of complex organic molecules

Upstream product

• 35480-95-6 4-isopropyl-2-nitro-benzoic acid 
• 586-61-8 4-iso-propylbromobenzene 
• 204850-14-6 1-bromo-4-isopropyl-2-nitrobenzene 
• 204850-15-7 4-isopropyl-2-nitrobenzonitrile 
• 943-15-7 2-nitro-p-cymene 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 99277-71-1 4-bromo-2-nitrobenzoic acid 

Downstream Products

• 943780-25-4 tert-butyl (S)-4-(2-(7-isopropylquinazolin-4-ylamino)-4-(1-phenylethylcarbamoyl)phenylthio)phenylcarbamate 
• 943780-27-6 (R)-4-(4-aminophenylthio)-N-(2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylquinazolin-4-ylamino)benzamide 
• 943780-22-1 (S)-4-(4-aminophenylthio)-3-(7-isopropylquinazolin-4-ylamino)-N-(1-phenylethyl)benzamide 
• 943780-29-8 4-(4-(tert-butoxycarbonylamino)phenylthio)-3-(7-isopropylquinazolin-4-ylamino)benzoic acid 
• 943780-28-7 methyl 4-(4-(tert-butoxycarbonylamino)phenylthio)-3-(7-isopropylquinazolin-4-ylamino)benzoate 
• 943780-24-3 4-chloro-7-isopropylquinazoline 
• 20154-41-0 4-isopropyl-2-hydroxybenzoic acid 

Relevant articles and documents

Selenium-catalyzed intramolecular atom- And redox-economical transformation ofo-nitrotoluenes into anthranilic acids

Anthranilic acids (AAs) are significant basic chemicals used in pharmaceuticals, agrochemicals, dyes, fragrances,etc. Superfluous steps are always involved in obtaining AAs. Herein, we demonstrate a straightforward strategy to transform abundanto-nitrotoluenes into biologically and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines,etc., can be tolerated in this transformation. A hundred-gram-scale operation is realized efficiently with almost quantitative selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species.

OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE

Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease

A series of 2-amino-4H-3,1-benzoxazin-4-ones have been synthesized and evaluated as inhibitors of the complement enzyme C1r. C1r is a serine protease at the beginning of the complement cascade, and complement activation by β-amyloid may represent a major contributing pathway to the neuropathology of Alzheimer's disease. Compounds such as 7-chloro-2-[(2- iodophenyl)amino]benz[d][1,3]oxazin-4-one (32) and 7-methyl-2-[(2- iodophenyl)amino]benz[d][1,3]oxazin-4-one (37) show improved potency compared to the reference compound FUT-175. Many of these active compounds also possess increased selectivity for C1r compared to trypsin and enhanced hydrolytic stability relative to 2-(2-iodophenyl)-4H-3,1-benzoxazin-4-one (1).