77458-30-1

Basic information

• Product Name: 1-(4-Chlorophenyl)-1H-pyrazol-4-ol
• Synonyms: 1-(4-Chlorophenyl)-1H-pyrazol-4-ol
• CAS NO: 77458-30-1
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Mol File: 77458-30-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-Chlorophenyl)-1H-pyrazol-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-1H-pyrazol-4-ol(77458-30-1)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-1H-pyrazol-4-ol(77458-30-1)

Safety Data

• Hazardous Substances Data: 77458-30-1(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 106-39-8 bromochlorobenzene 
• 334832-82-5 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 1227674-56-7 C₂₁H₁₇Cl₅N₂O₃ 
• 84260-11-7 O-[1-(4-chlorophenyl)pyrazol-4-yl]-O,O-diethyl phosphite 
• 77458-01-6 (RS)-O-1-(4-chlorophenyl)pyrazol-4-yl O-ethyl S-propyl phosphorothioate 

Relevant articles and documents

Sequential Xanthalation and O-Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers

Molecules containing trifluoromethoxyaryl groups are of interest in pharmaceutical, agrochemical, and materials science research, due to their unique physical and electronic properties. Many of the known methods to synthesize aryl trifluoromethyl ethers require harsh reagents and highly controlled reaction conditions and rarely occur when heteroaromatic units are present. The two-step O-trifluoromethylation of phenols via aryl xanthates is one such method that suffers from these drawbacks. Herein, we report a method for the synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salts and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions.

Biguanide derivatives, pharmaceutical composition, preparation method and application

The invention belongs to the field of medicine and particularly relates to biguanide derivatives, pharmaceutical composition, a preparation method and an application. The biguanide derivatives are compounds with the structure shown in the description, or pharmaceutically acceptable salts, solvates, isomers, esters and predrugs of the compounds. The compounds can remarkably inhibit proliferation and migration of tumor cells, IC50 is greatly lower than that of metformin and phenformin before derivatization, the compound 11 has the highest activity, and activity of the compounds in UMUC3, T24 andA2780 cells is more than 300-800 times that of metformin, and the compounds have good application prospect in antitumor drugs.

Pyrazol-4-yl phosphates and insecticidal and acaricidal use

Pyrazol-4-yl phosphates of the formula STR1 wherein R1 represents a lower alkyl group, R2 is a lower alkoxy group or a lower alkylthio group, R3 represents hydrogen or a lower alkoxycarbonyl group, X is oxygen or sulfur atom, Y represents a lower alkyl, a lower alkoxy or a lower alkylthio group, a halogen atom, nitro or trifluoromethyl, and n is zero or an integer of 1, 2 or 3, or Yn represents an alkylidenedioxy containing 1 to 3 carbon atoms, have marked insecticidal-acaricidal activity against household pests, plant pests, mites, etc. without substantial toxicity to warm-blooded animals and fishes.