774604-08-9

Basic information

• Product Name: C₁₈H₂₈N₂O*C₄₂H₇₀O₃₅*ClH
• CAS NO: 774604-08-9
• Molecular Weight: 1459.89
• Mol File: 774604-08-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₈N₂O*C₄₂H₇₀O₃₅*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₈N₂O*C₄₂H₇₀O₃₅*ClH(774604-08-9)
• EPA Substance Registry System: C₁₈H₂₈N₂O*C₄₂H₇₀O₃₅*ClH(774604-08-9)

Safety Data

• Hazardous Substances Data: 774604-08-9(Hazardous Substances Data)

Upstream product

• 14252-80-3 bupivacaine hydrochloride 
• 7585-39-9 β‐cyclodextrin 

Relevant articles and documents

Phase solubility, 1H NMR and molecular modelling studies of bupivacaine hydrochloride complexation with different cyclodextrin derivates

A novel method, which simultaneously exploits experimental (NMR) and theoretically calculated data obtained by a molecular modelling technique, was proposed, to obtain deeper insight into inclusion geometry and possible stereoselective binding of bupivacaine hydrochloride with selected cyclodextrin derivatives. Sulphobuthylether-β-cyclodextrin and water soluble polymeric β-cyclodextrin demonstrated to be the best complexing agents for the drug, resulting in formation of the most stable inclusion complexes with the highest increase in aqueous drug solubility. The drug-carrier binding modes with these cyclodextrins and phenomena which may be directly related to the higher stability and better aqueous solubility of complexes formed were discussed in details.