774607-99-7

Basic information

• Product Name: 2-Pyrimidinamine, 5-bromo-4-chloro-6-(5-chloro-2-methoxyphenyl)-
• CAS NO: 774607-99-7
• Molecular Formula: C11H8BrCl2N3O
• Molecular Weight: 349.014
• Mol File: 774607-99-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyrimidinamine, 5-bromo-4-chloro-6-(5-chloro-2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 5-bromo-4-chloro-6-(5-chloro-2-methoxyphenyl)-(774607-99-7)
• EPA Substance Registry System: 2-Pyrimidinamine, 5-bromo-4-chloro-6-(5-chloro-2-methoxyphenyl)-(774607-99-7)

Safety Data

• Hazardous Substances Data: 774607-99-7(Hazardous Substances Data)

Upstream product

• 7781-26-2 2-amino-5-bromo-4,6-dichloropyrimidine 
• 89694-48-4 5-chloro-2-methoxyphenyl boronic acid 
• 3375-31-3 palladium diacetate 
• 774607-79-3 4-chloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-2-yl-amine 

Relevant articles and documents

Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists

The identification and hit-to-lead exploration of a novel, potent and selective series of histamine H4 receptor inverse agonists is described. The initial hit, 3A (IC50 19 nM) was identified by means of a ligand-based virtual screening approach. Subsequent medicinal chemistry exploration yielded 18I which possessed increased potency (R-enantiomer IC50 1 nM) as well as enhanced microsomal stability.

Pyrimidines and uses thereof

The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.