7748-59-6

Basic information

• Product Name: 1,2-DINITRO-4,5-METHYLENEDIOXYBENZENE
• Synonyms: 1,2-DINITRO-4,5-METHYLENEDIOXYBENZENE;5,6-DINITRO-1,3-BENZODIOXOLE;1,2-(Methylenedioxy)-4,5-dinitro-benzene;4,5-Methylenedioxy-1,2-dinitrobenzene;5,6-Dinitrobenzo[d][1,3]dioxole
• CAS NO: 7748-59-6
• Molecular Formula: C₇H₄N₂O₆
• Molecular Weight: 212.12
• Product Categories: Aldehyde Labeling Reagents;Aromatics
• Mol File: 7748-59-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 80-82°C
• Boiling Point: 392.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.706±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1,2-DINITRO-4,5-METHYLENEDIOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DINITRO-4,5-METHYLENEDIOXYBENZENE(7748-59-6)
• EPA Substance Registry System: 1,2-DINITRO-4,5-METHYLENEDIOXYBENZENE(7748-59-6)

Safety Data

• Hazardous Substances Data: 7748-59-6(Hazardous Substances Data)

Usage

Description

1,2-Dinitro-4,5-methylenedioxybenzene, with the CAS number 7748-59-6, is an organic compound characterized by the presence of two nitro groups (-NO2) at the 1 and 2 positions and a methylenedioxy group (-O-CH2-O-) at the 4 and 5 positions on a benzene ring. This chemical structure endows it with unique properties that make it valuable in various applications.

Uses

Used in Organic Synthesis:
1,2-Dinitro-4,5-methylenedioxybenzene is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for a range of chemical reactions, such as reduction, substitution, and rearrangement, which can lead to the formation of diverse products with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,2-dinitro-4,5-methylenedioxybenzene can be used as a building block for the development of new drugs. Its chemical properties make it a versatile starting material for the synthesis of various drug candidates, particularly those with potential applications in the treatment of various diseases.
Used in Chemical Research:
1,2-Dinitro-4,5-methylenedioxybenzene is also utilized in chemical research as a model compound for studying reaction mechanisms and exploring new synthetic routes. Its unique structure provides researchers with valuable insights into the reactivity and behavior of similar compounds, contributing to the advancement of chemical knowledge and the development of new synthetic strategies.
Used in Material Science:
In the field of material science, 1,2-dinitro-4,5-methylenedioxybenzene can be employed in the development of novel materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with enhanced characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various industrial processes.

Upstream product

• 274-09-9 Methylenedioxybenzene 
• 94-53-1 Piperonylic acid 
• 75-11-6 diiodomethane 
• 77400-30-7 1,2-dihydroxy-4,5-dinitrobenzene 
• 2620-44-2 5-nitro-1,3-benzodioxole 
• 144-55-8 sodium hydrogencarbonate 
• 716-32-5 6-nitrobenzo[d][1,3]dioxole-5-carboxylic acid 
• 120-57-0 piperonal 

Downstream Products

• 81864-15-5 1,2-diamino-4,5-methylenedioxybenzene dihydrochloride 
• 38608-07-0 1,2-methylenedioxy-4,5-diaminobenzene 
• 105780-30-1 1,2-Dinitro-4-hydroxy-5-methoxybenzene 
• 105780-37-8 4,5-dinitro-2-[β-(2-hydroxyethoxy)ethoxy]phenol 
• 105780-32-3 4,5-dinitro-2-(β-methoxyethoxy)phenol 

Relevant articles and documents

HETEROCYCLIC LSF INHIBITORS AND THEIR USES

The present invention is directed to heterocyclic SV40 Factor (LSF) inhibitors and their uses. In some implementations, the present invention discloses small-molecule compounds of Formula (I). In some implementations, the compounds of Formula (I) are used

Robust Photocatalytic Method Using Ethylene-Bridged Flavinium Salts for the Aerobic Oxidation of Unactivated Benzylic Substrates

7,8-Dimethoxy-3-methyl-1,10-ethylenealloxazinium chloride (1a) was found to be a superior photooxidation catalyst among substituted ethylene-bridged flavinium salts (R=7,8-diMeO, 7,8-OCH2O-, 7,8-diMe, H, 7,8-diCl, 7-CF3 and 8-CF3). Selection was carried out based on structure vs catalytic activity and properties relationship investigations. Flavinium salt 1a proved to be robust enough for practical applications in benzylic oxidations/oxygenations, which was demonstrated using a series of substrates with high oxidation potential, i. e., 1-phenylethanol, ethylbenzene, diphenylmethane and diphenylmethanol derivatives substituted with electron-withdrawing groups (Cl or CF3). The unique capabilities of 1a can be attributed to its high photostability and participation via a relatively long-lived singlet excited state, which was confirmed using spectroscopic studies, electrochemical measurements and TD-DFT calculations. This allows the maximum use of the oxidation power of 1a, which is given by its singlet excited state reduction potential of +2.4 V. 7,8-Dichloro-3-methyl-1,10-ethylenealloxazinium chloride (1 h) can be used as an alternative photocatalyst for even more difficult substrates. (Figure presented.).

Quinoxalin -2 (1H)-ketone compound and its preparation method and application

The invention relates to a 1-substituted-6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone compound which is shown as the formula (I), preparation method and an application thereof. The benzodioxole is used as the raw material and subjected to nitration reaction for two times to produce the dinitration product: 5,6-dinitrobenzo[d][1,3] dioxacyclopentane, the 5,6-dinitrobenzo[d][1,3] dioxacyclopentane is subjected to ring opening under conditions of strong alkaline to obtain the ring opening product: 2-methoxy-4,5-dinitrophenol, the 2-methoxy-4,5-dinitrophenol and 4-(3-chloropropyl) morpholine are allowed to perform nucleophilic substitution, so as to obtain 4-(3-(2- methoxy-4,5-dinitrophenoxy) propyl) morpholine, the 4-(3-(2- methoxy-4,5-dinitrophenoxy) propyl) morpholine is reduced and allowed to perform ring closing reaction with ethyl glyoxalate to produce 6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone, and finally the 6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone is allowed to react with halogenated hydrocarbon containing substituents R under the alkaline condition, so as to produce the 1-substituted-6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone compound. The ketone compound has inhibition effect on EGFR kinase.(img file='DDA0000468270950000011.TIF' wi='928' he='416'/).