77484-99-2

Basic information

• Product Name: METHYL 4H-FURO[3,2-B]PYRROLE-5-CARBOXYLATE
• Synonyms: 4H-FURO[3,2-B]PYRROLE-5-CARBOXYLIC ACID METHYL ESTER;METHYL 4H-FURO[3,2-B]PYRROLE-5-CARBOXYLATE;Methyl 4H-furo[3,2-b]pyrrole-5-carboxylate 97%;5-(Methoxycarbonyl)-4H-furo[3,2-b]pyrrole;furopyrrole-5-carboxylic acid Methyl ester;Methyl4H-furo[3,2-b]pyrrole-5-carboxylate97%
• CAS NO: 77484-99-2
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 77484-99-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 139 °C
• Boiling Point: 286.363 °C at 760 mmHg
• Flash Point: 126.988 °C
• Appearance: /
• Density: 1.348 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: 2-8°C
• PKA: 14.22±0.30(Predicted)
• CAS DataBase Reference: METHYL 4H-FURO[3,2-B]PYRROLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4H-FURO[3,2-B]PYRROLE-5-CARBOXYLATE(77484-99-2)
• EPA Substance Registry System: METHYL 4H-FURO[3,2-B]PYRROLE-5-CARBOXYLATE(77484-99-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77484-99-2(Hazardous Substances Data)

Usage

General Description

Methyl 4H-furo[3,2-b]pyrrole-5-carboxylate is a chemical compound with a unique heterocyclic structure, consisting of a furo-pyrrole core with a methyl ester group attached to the carboxylate moiety. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of complex molecules. METHYL 4H-FURO[3,2-B]PYRROLE-5-CARBOXYLATE has shown potential in various biological activities such as anticancer, antibacterial, and antiviral properties. Its versatile structure makes it a valuable intermediate for the development of new drugs and agrochemicals. Additionally, it has garnered attention for its potential use in materials science and new methodologies for chemical synthesis.

InChI:InChI=1/C8H7NO3/c1-11-8(10)6-4-7-5(9-6)2-3-12-7/h2-4,9H,1H3

Upstream product

• 102244-88-2 β-(2-Furyl)-α-azidoacrylsaeuremethylester 
• 164667-41-8 methyl 2-azido-2-(furan-2-yl)acrylate 
• 98-01-1 furfural 

Downstream Products

• 892398-08-2 4-(2-oxo-2-phenyl-ethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid methyl ester 
• 67268-37-5 4H-furo[3,2-b]pyrrole-5-carboxylic acid 
• 1146291-70-4 4-(4-chlorobenzyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid 
• 1263388-08-4 2-methoxyphenyl 4H-furo[3,2-b]pyrrole-5-carboxylate 
• 1007388-09-1 methyl 6-bromo-4H-furo[3,2-b]pyrrole-5-carboxylate 
• 892398-11-7 4-(2-oxo-2-phenyl-ethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid 

Relevant articles and documents

PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE

The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.

PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE

The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D- amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.

Bicyclic pyrrole derivatives as MCP-1 inhibitors

A pharmaceutical composition comprising a compound of formula (I): or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1 and wherein A and B together form an optionally substituted 5-member aromatic ring which includes at least one heteroatom; R1is an optionally substituted aryl or heteroaryl ring; R2is selected from a range of organic groups including carboxy, and R3is hydrogen, or a range of organic groups; in combination with a pharmaceutically acceptable carrier. Certain compounds of formula (I) are novel and these form a further aspect of the invention.