7752-46-7

Basic information

• Product Name: 2-AMINO-4-MORPHOLINO-6-METHYLPYRIMIDINE
• Synonyms: 2-AMINO-4-MORPHOLINO-6-METHYLPYRIMIDINE;4-METHYL-6-MORPHOLINO-2-PYRIMIDINAMINE;4-METHYL-6-MORPHOLINO-2-PYRIMIDINYLAMINE;2-Amino-4-methyl-6-morpholinopyrimidine;4-methyl-6-morpholin-4-yl-pyrimidin-2-ylamine
• CAS NO: 7752-46-7
• Molecular Formula: C9H14N4O
• Molecular Weight: 194.23
• Mol File: 7752-46-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 451.7 °C at 760 mmHg
• Flash Point: 227 °C
• Appearance: /
• Density: 1.231 g/cm³
• Vapor Pressure: 2.38E-08mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 2-AMINO-4-MORPHOLINO-6-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-MORPHOLINO-6-METHYLPYRIMIDINE(7752-46-7)
• EPA Substance Registry System: 2-AMINO-4-MORPHOLINO-6-METHYLPYRIMIDINE(7752-46-7)

Safety Data

• Hazardous Substances Data: 7752-46-7(Hazardous Substances Data)

Usage

General Description

2-AMINO-4-MORPHOLINO-6-METHYLPYRIMIDINE is a chemical compound that belongs to the pyrimidine group. It consists of a pyrimidine ring with an amino group at the 2-position, a morpholino group at the 4-position, and a methyl group at the 6-position. 2-AMINO-4-MORPHOLINO-6-METHYLPYRIMIDINE is often used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals. It has been investigated for its anti-tumor and anti-inflammatory properties, and has shown potential as a therapeutic agent for the treatment of certain types of cancer and other diseases. In addition, it is also used as a research tool in biological and biochemical studies to investigate its interactions with various targets in the body.

InChI:InChI=1/C9H14N4O/c1-7-6-8(12-9(10)11-7)13-2-4-14-5-3-13/h6H,2-5H2,1H3,(H2,10,11,12)

Upstream product

• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 
• 110-91-8 morpholine 
• 5600-21-5 2-amino-6-methyl-4-chloropyrimidine 
• 7732-18-5 water 

Downstream Products

• 1227926-35-3 2-hydroxy-6-methyl-8-morpholin-4-yl-4H-pyrimido[1,2-a]pyrimidin-4-one 

Relevant articles and documents

Proton Sensitive Functional Organic Fluorescent Dyes Based on Coumarin-imidazo[1,2-a]pyrimidine; Syntheses, Photophysical Properties, and Investigation of Protonation Ability

A novel series of 2-coumarin-3-yl-imidazo[1,2-a]pyrimidines have been synthesized with functionalized coumarin and pyrimidine units of the different architecture to give various fluorescent compounds. A new additional series bearing unsubstituted coumarin and 7-dialkylaminocoumarin as fluorophore were obtained by palladium-catalyzed cross-coupling reactions, through coupling of 6-bromo-2-coumarin-3-yl-imidazopyrimidine derivatives with various arylboronic acids. In the all reaction step, microwave irradiation (MWI) method was used and compared with the conventional method (CM). Photophysical properties of synthesized compounds were studied by a combination of UV/Vis and fluorescence spectroscopy in various solvents having different polarities. The protonation abilities of all compounds were investigated by titration with trifluoroacetic acid (TFA) in dichloromethane. In both series, the compounds bearing 7-dialkylaminocoumarin are fluorescently active even in daylight and showed maximum absorption wavelengths (λabs–max) in the visible region in all solvents used. In addition, they showed drastic color and emission change in acidic environment. Moreover, for the investigation of protonation ability of three selected compounds bearing 7-dialkylaminocoumarin have been studied using a buffer solution with various pH and determinated their pKa values. The compound bearing morpholine has the potential to use as colorimetric and luminescence pH sensor. The thermal properties of all the synthesized compounds were also evaluated with TGA to test their usability as optic dyes.