77521-29-0 Usage
Description
(RS)-AMPA, also known as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, is a potent and selective agonist of the excitatory neurotransmitter L-glutamic acid. It is a racemic mixture containing an equal proportion of the active (S)-enantiomer and the inactive (R)-enantiomer. (RS)-AMPA plays a crucial role in the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Its unique property of not interfering with binding sites for kainic acid or NMDA allows for the distinction of AMPA receptor-specific activity in neuronal responses.
Uses
Used in Neuropharmacological Research:
(RS)-AMPA is used as a research tool for studying the role of AMPA receptors in various neuronal processes. Its ability to selectively activate AMPA receptors without interference from kainic acid or NMDA binding sites makes it an ideal candidate for investigating AMPA receptor-specific activity and its contribution to neuronal responses.
Used in Drug Development:
(RS)-AMPA serves as a starting point for the development of drugs targeting AMPA receptors. By understanding the interactions between (RS)-AMPA and AMPA receptors, researchers can design and synthesize novel compounds with improved selectivity, potency, and efficacy for the treatment of neurological disorders associated with AMPA receptor dysfunction.
Used in Neurodegenerative Disease Research:
(RS)-AMPA is employed as a research compound to study the involvement of AMPA receptors in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. By examining the effects of (RS)-AMPA on neuronal excitation and AMPA receptor activity, researchers can gain insights into the underlying mechanisms of these diseases and develop potential therapeutic strategies.
Used in Synaptic Plasticity Studies:
(RS)-AMPA is utilized in research focused on synaptic plasticity, a phenomenon that underlies learning and memory processes. By modulating AMPA receptor activity, (RS)-AMPA can help researchers explore the molecular and cellular mechanisms governing synaptic plasticity and its implications in cognitive functions.
Used in Neuroprotection Research:
(RS)-AMPA is used in studies aimed at understanding the neuroprotective effects of AMPA receptor modulation. By investigating the impact of (RS)-AMPA on neuronal excitation and AMPA receptor activity under various conditions, researchers can identify potential neuroprotective agents and therapeutic approaches for preventing neuronal damage and promoting neuronal survival.
Biological Activity
More water soluble hydrobromide salt of ( RS )-AMPA ((RS)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid ).
Check Digit Verification of cas no
The CAS Registry Mumber 77521-29-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,5,2 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77521-29:
(7*7)+(6*7)+(5*5)+(4*2)+(3*1)+(2*2)+(1*9)=140
140 % 10 = 0
So 77521-29-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
77521-29-0Relevant articles and documents
An efficient and general enantioselective synthesis of some isoxazole- containing analogues of the neuroexcitant glutamic acid
Pajouhesh, Hassan,Curry, Kenneth
, p. 2757 - 2760 (1998)
Isoxazole amino acids are an important class of neuroexcitant which are difficult to prepare in enantiopure form. Diastereoselective alkylation of the enantiomerically pure glycine derivative, tert-butoxycarbonyl-2-(tert- butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (Boc-BMI) with 4- bromomethyl-2-methoxymethyl-5-methylisoxazolin-5-one 5 or 5-bromomethyl-4- bromo-3-methoxyisoxazole, gives intermediates which under mild hydrolysis conditions produce the amino acids (S)- and (R)-bromohomoibotenic acid and (S)- and (R)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionic acid with e.e. >99%.
