7753-75-5Relevant articles and documents
Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms
Hayes, Martin A.,Roberts, Ieuan,Gr?nberg, Gunnar,Lv, Kexin,Lin, Baorui,Bergare, Jonas,Elmore, Charles S.
, p. 221 - 229 (2017/04/10)
1β–hydroxydeoxycholic acid in unlabeled and stable isotope labeled forms was required for use as a biomarker for Cytochrome P450 3A4/5 activity. A lengthy synthesis was undertaken to deliver the unlabeled compound and in the process, to develop a route to the deuterium labeled compound. The synthesis of the unlabeled compound was completed but in a very low yield. Concurrent with the synthetic approach, a biosynthetic route was pursued and this approach proved to be much more rapid and afforded the compound in both unlabeled and deuterium labeled forms in a 1-step oxidation from deoxycholic acid and [D4]deoxycholic acid, respectively.
Partial synthesis of a marine secosterol from Gersemia fruticosa: Preparation of the intermediate precursor 3β,6α-diacetoxy-24-methyl-12-oxo-5α-chol-9,11-en-24-oate
Kuhl, Alexander,Kreiser, Wolfgang
, p. 1145 - 1148 (2007/10/03)
The conversion of desoxycholic acid (2) into the title compound 14 by 13 respectively 17 steps is described herein, including stereoselective construction of C-3 and C-6 hydroxy moieties and introduction of a Δ9,11 double bond by dehydrogenation. 14 is believed to serve as a putative precursor for the synthesis of secosterol 1, isolated from the soft coral Gersemia fruticosa.
Direct transformation of steroidal ethers into ketones by dimethyldioxirane
Van Heerden,Dixon,Holzapfel
, p. 7399 - 7402 (2007/10/02)
Treatment of the methyl- and benzyl ethers of 3-hydroxy steroids with a solution of dimethyldioxirane resulted in the formation of the corresponding ketones in high yield.
