775350-02-2Relevant articles and documents
Ring-substituted imidazoles as a new class of anti-tuberculosis agents
Gupta, Preeti,Hameed, Shahul,Jain, Rahul
, p. 805 - 814 (2004)
We describe in vitro anti-Mycobacterium tuberculosis activities of ring-substituted-1H-imidazole-4-carboxylic acid derivatives (1-6), and 3-(2-alkyl-1H-imidazol-4-yl)-propionic acid derivatives (7-13) against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most effective analogues, 2f (R=R1=c-C5H9), and 2h (R=R1=c-C6H11) have produced >90% inhibition at a concentration of 6.25 μg/ml in the drug-sensitive screen. Upon further evaluation against drug-resistant strains, both analogues 2f and 2h produced an MIC value of 25.0 μg/ml. The observation of significant anti-tuberculosis activity in some of these analogues describes the discovery of novel ring-substituted-1H-imidazole-4-carboxylic acid ethyl esters as a new class of anti-tuberculosis agents.
