776297-01-9

Basic information

• Product Name: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate
• Synonyms: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate
• CAS NO: 776297-01-9
• Molecular Weight: 288.367
• Mol File: 776297-01-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate(776297-01-9)
• EPA Substance Registry System: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate(776297-01-9)

Safety Data

• Hazardous Substances Data: 776297-01-9(Hazardous Substances Data)

Upstream product

• 13669-10-8 ethyl 2-thenoylacetate 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 1202634-50-1 ethyl 2-(2-thiophenecarbonyl)-3-phenylacrylate 
• 591-50-4 iodobenzene 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 301164-69-2 (1H-benzo[d][1,2,3]triazol-1-yl)(thiophen-2-yl)methanone 

Downstream Products

• 109399-10-2 4-benzyl-2-(1-methyl-[4]piperidyl)-5-[2]thienyl-1,2-dihydro-pyrazol-3-one 

Relevant articles and documents

Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements

An organocatalytic asymmetric process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20?:?1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability.

Method for preparing alpha-alkyl-beta-ketone ester compound

The invention discloses a method for preparing an alpha-alkyl-beta-ketone ester compound shown as a formula (I). The method comprises the following steps: a 1,4-dihydropyridine ester compound shown asa formua (III) is taken as a reducing agent, and under existence of a Lewis acid catalyst, a compound in a formula (II) is subjected to a reduction reaction to obtain the alpha-alkyl-beta-ketone ester compound shown as the formula (I). The method has the advantages of simple operation, mild condition and environmental protection, and is suitable for a plurality of substrates, and the yield can reach as highest as 95%. By using the method of the invention, a plurality of alpha-alkyl-beta-ketone ester compounds can be efficiently prepared, types of medical intermediates are enriched, and the method has an excellent industrial application prospect.

Heck reaction of Baylis-Hillman adducts with iodobenzenes using a catalytic amount of Pd/C under solvent-free conditions

The reaction of Baylis-Hillman adducts with iodobenzenes using commercially available palladium-on-carbon as a catalyst under solvent-free conditions afforded the corresponding coupling products, α-benzyl-β-keto esters, in high to excellent yields. The reactions are very efficient.