77640-03-0 Usage
Description
3-(1-METHYL-1H-PYRROL-2-YL)-3-OXOPROPANENITRILE, also known as 2-Cyanoacetyl-N-methylpyrrole (CAS# 77640-03-0), is a solid compound with significant utility in the field of organic synthesis. Its unique chemical structure, featuring a nitrile group and a pyrrole ring, makes it a versatile building block for the creation of various complex organic molecules.
Uses
Used in Organic Synthesis:
3-(1-METHYL-1H-PYRROL-2-YL)-3-OXOPROPANENITRILE is used as a synthetic building block for the development of complex organic molecules. Its application in organic synthesis is due to its unique chemical structure, which allows for further functionalization and the creation of a wide range of compounds with diverse properties and potential applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(1-METHYL-1H-PYRROL-2-YL)-3-OXOPROPANENITRILE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to be functionalized and incorporated into more complex molecular structures makes it a valuable asset in the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
3-(1-METHYL-1H-PYRROL-2-YL)-3-OXOPROPANENITRILE is also utilized in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic pathways. Its unique structure provides researchers with opportunities to investigate novel chemical transformations and develop innovative methodologies in organic chemistry.
Used in Material Science:
In the field of material science, 3-(1-METHYL-1H-PYRROL-2-YL)-3-OXOPROPANENITRILE can be used as a component in the development of novel materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with enhanced characteristics, such as improved stability, conductivity, or other desirable properties.
Check Digit Verification of cas no
The CAS Registry Mumber 77640-03-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,6,4 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 77640-03:
(7*7)+(6*7)+(5*6)+(4*4)+(3*0)+(2*0)+(1*3)=140
140 % 10 = 0
So 77640-03-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2O/c1-10-6-2-3-7(10)8(11)4-5-9/h2-3,6H,4H2,1H3
77640-03-0Relevant articles and documents
Cyanoacetylazoles and salicylic aldehydes promoting the synthesis of new trifluoromethyl-substituted azolecarbonyl-2H-chromen-2-ones through the Knoevenagel condensation reaction
Bonacorso, Helio G.,Rodrigues, Melissa B.,Rosa, Wilian C.,Silva, Letícia B.,Frizzo, Clarissa P.,Zanatta, Nilo,Martins, Marcos A.P.
, p. 296 - 305 (2015)
The results of the chemical behavior of three substituted cyanoacetylazoles and some salicylic aldehydes used to obtain new trifluoromethylated azolecarbonyl-2H-chromen-2-ones through Knoevenagel condensation reactions, are reported. First, a new series of four 3-(5-hydroxy-3-methyl-5-trifluoromethyl-4,5-dihydro-1H-pyrazole-1-carbonyl)-2-imino-2H-chromenes were efficiently synthesized, in yields of 50-78%, using 0.4 M NaOH/EtOH as the catalyst. They were then subjected to an acid hydrolysis reaction, which produced the respective trifluoromethyl-substituted pyrazolinecarbonyl coumarins in good yields (80-91%). In order to study the influence of the CF3 substituent, reactions involving 1-cyanoacetyl-3,5-dimethyl-5-hydroxy-4,5-dihydro-1H-pyrazole were also performed, but they did not provide the desired coumarins. On the other hand, attempts to synthesize some pyrrolecarbonyl coumarins not containing trifluoromethyl groups, but using the same methodology, directly resulted in a new series of five 3-(1-methyl-1H-pyrrol-2-carbonyl)-2H-chromen-2-ones in good yields (40-60%).
Synthesis of π-conjugated thiophenes starting from substituted 3-oxopropanenitriles via Gewald reaction
Puterová, Zita,Andicsová, Anita,Végh, Daniel
experimental part, p. 11262 - 11269 (2009/04/06)
This paper describes the synthesis of β-aryl and β-heteroaryl substituted 2-aminothiophenes as a novel class of building blocks in oligo- and polythiophenes. The synthesis was carried out in two steps, involving synthesis of substituted 3-oxopropanenitrile intermediates, followed by the Gewald reaction.
Alphacarbamoyl-pyrrolpropionitriles
-
, (2008/06/13)
1-Substituted-β-oxo-α-phenylcarbamoyl-pyrrolpropionitriles, e.g. those of the formula STR1 their alkylenol ethers or alkanoylenol esters and salts thereof are antiinflammatory and antiarthritic agents.
