77746-63-5

Basic information

• Product Name: Methanimidamide, N'-[4-formyl-1-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-5-yl]-N,N-dimeth yl-
• CAS NO: 77746-63-5
• Molecular Formula: C20H20N4O2
• Molecular Weight: 348.404
• Mol File: 77746-63-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanimidamide, N'-[4-formyl-1-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-5-yl]-N,N-dimeth yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanimidamide, N'-[4-formyl-1-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-5-yl]-N,N-dimeth yl-(77746-63-5)
• EPA Substance Registry System: Methanimidamide, N'-[4-formyl-1-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-5-yl]-N,N-dimeth yl-(77746-63-5)

Safety Data

• Hazardous Substances Data: 77746-63-5(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 39232-91-2 m-methoxyphenylhydrazine hydrochloride 
• 614-16-4 Benzoylacetonitrile 
• 41554-51-2 5-amino-1-(4-methoxylphenyl)-3-phenyl-1H-pyrazole 

Downstream Products

• 1400634-65-2 1-(4-methoxylphenyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine 

Relevant articles and documents

One-Pot Acid-Promoted Synthesis of 6-Aminopyrazolopyrimidines from 1 H-Pyrazol-5-yl- N, N-dimethylformamidines or 5-Amino-1 H-pyrazole-4-carbaldehydes with Cyanamide

A convenient and efficient one-pot acid-promoted synthesis of 6-aminopyrazolo[3,4-d]pyrimidine has been developed by treatment of 1H-pyrazol-5-yl-N,N-dimethylformamidines or 5-amino-1H-pyrazole-4-carbaldehydes with cyanamide (NH2CN) in an acid-

VILSMEIER-HAACK REACTION OF 5-AMINO- AND 5-ACYLAMINO-PYRAZOLES

The Vilsmeier-Haack reaction of 5-aminopyrazole derivatives 1 was investigated in view of contradictory literature reports.Structure 2 of the products was proved both chemically and spectroscopically.The mechanism of the reaction was postulated on the basis of isolated intermediates 7 and 8. 5-Acylaminopyrazoles 9, 10 and 11 were found to give also 2 (and 7) under the Vilsmeier conditions by an acyl splitting reaction, proceeding probably via diacylamino derivatives 12.Compounds 2 provided a simple route to pyrazolopyrimidine derivatives 13 and 14 as well as to azomethine compounds 15-18.