7780-20-3

Basic information

• Product Name: piperine
• Synonyms: 1-[5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine;1-Piperidino-5-(1,3-benzodioxole-5-yl)-2,4-pentadiene-1-one;Piperine;Piperidine, 1-[5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl]-
• CAS NO: 7780-20-3
• Molecular Formula: C17H19NO3
• Molecular Weight: 285.37
• EINECS: 202-348-0
• Mol File: 7780-20-3.mol
• Article Data: 33

Chemical Properties

• Melting Point: 128-132℃
• Boiling Point: 498.524 °C at 760 mmHg
• Flash Point: 255.298 °C
• Appearance: /
• Density: 1.212 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.615
• PKA: -0.71±0.20(Predicted)
• Water Solubility: 40 mg/L (18℃)
• CAS DataBase Reference: piperine(CAS DataBase Reference)
• NIST Chemistry Reference: piperine(7780-20-3)
• EPA Substance Registry System: piperine(7780-20-3)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R21/22:
• Safety Statements: S36/37:
• Hazardous Substances Data: 7780-20-3(Hazardous Substances Data)

Usage

General Description

Piperine is a natural alkaloid compound found in black pepper that is responsible for its pungent flavor. It has been found to have numerous health benefits, including anti-inflammatory, antioxidant, and anti-cancer properties. Additionally, piperine has been shown to enhance the absorption and bioavailability of other nutrients and drugs in the body, making it a valuable compound for improving overall health and wellness. It is also known for its potential to aid in weight loss and improve gastrointestinal function. Overall, piperine is a powerful and versatile chemical compound with a wide range of potential health benefits.

InChI:InChI=1/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2-,7-3+

Upstream product

• 110-89-4 piperidine 
• 94-62-2 Piperine 
• 50838-22-7 1-crotonoylpiperidine 
• 120-57-0 piperonal 
• 136-72-1 piperic acid 
• 1796-25-4 1-(2-bromoacetyl)piperidine 
• 58095-77-5 (E)-3,4-methylenedioxycinnamaldehyde 
• 504-31-4 pyran-2-one 
• 22980-23-0 2-oxa-3-oxobicyclo[2.2.0]hex-5-ene 
• 71627-26-4 1-<5-(1,3-benzodioxol-5-yl)-1-oxo-3,4-pentadienyl>piperidine 
• 3204-68-0 benzyldimethylphenylammonium chloride 
• 41193-98-0 1-(4-oxo-butyryl)-piperidine 
• 495-76-1 piperonol 
• 20850-43-5 5-(chloromethyl)-1,3-benzodioxole 

Downstream Products

• 147429-43-4 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadien-1-yl)-piperidine 
• 90778-74-8 N-piperoylglycine 
• 1033757-14-0 N-(2-hydroxyethyl)-3-nitro-4-[2-(piperidin-1-ylcarbonyl)pyrrol-1-yl]benzamide 
• 1033757-18-4 3-amino-4-[4-(benzo[1,3]dioxol-5-yl)-4-hydroxy-1-(piperidin-1-ylcarbonyl)but-2-enylamino]-N-(2-hydroxyethyl)benzamide 
• 1033757-01-5 C₂₄H₂₄N₄O₇ 
• 1033757-15-1 3-nitro-4-[2-(piperidin-1-ylcarbonyl)pyrrol-1-yl]benzamide 
• 1033757-21-9 3-(benzo[1,3]dioxol-5-yl)-6-(piperidin-1-ylcarbonyl)-3,6-dihydro-[1,2]oxazine-2-carboxylic acid 4-carbamoylbenzyl ester 
• 1033756-91-0 6-(benzo[1,3]dioxol-5-yl)-3-(piperidin-1-ylcarbonyl)-3,6-dihydro-[1,2]oxazine-2-carboxylic acid 4-carbamoylbenzyl ester 

Relevant articles and documents

Vicinal difluorination as a C=C surrogate: An analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity

Piperine, a natural product derived from peppercorns, has a variety of biological activities that make it an attractive lead compound for medicinal chemistry. However, piperine has some problematic physicochemical properties including poor aqueous solubility and a susceptibility to UV-induced degradation. In this work, we designed an analog of piperine in which the central conjugated hydrocarbon chain is replaced with a vicinal difluoroalkane moiety. We show that this fluorinated analog of piperine has superior physicochemical properties, and it also has higher potency and selectivity towards one particular drug target, acetylcholinesterase. This work highlights the potential usefulness of the threo-difluoroalkane motif as a surrogate for E-alkenes in medicinal chemistry.

An Ir3L2complex with anion binding pockets: photocatalyticE-Zisomerizationviamolecular recognition

A molecular host with photosensitizing centers provides photo-responsive host-guest properties based on its molecular recognition ability. Here, we construct a self-assembled photoactive Ir(iii) cage-shaped complex that contains anion binding pockets on its rim. The anion recognition ability of the complex enables efficient catalysis of the visible-light-inducedE-Zisomerization of an anionic styrene derivative.

Piperine derivative as well as preparation method and application thereof

The invention provides a piperine derivative as well as a preparation method and an application thereof. The piperine derivative is a compound shown as a formula (I), or a salt thereof, or a stereoisomer thereof, or a hydrate thereof. The compound provided by the invention can effectively protect nerve cells and improve the survival rate of the nerve cells, so that the compound provided by the invention can effectively treat neurodegenerative diseases and can be used for preparing medicines for treating the neurodegenerative diseases.