7790-94-5

Basic information

• Product Name: Chlorosulfonic acid
• Synonyms: acidechlorosulfonique;chlorosulfonic;monochlorosulfuricacid;sulfonicacid,monochloride;AKOS BBS-00004309;CHLOROSULFONIC ACID;SULFURIC CHLOROHYDRIN;chlorosulphonic acid
• CAS NO: 7790-94-5
• Molecular Formula: ClHO₃S
• Molecular Weight: 116.52
• EINECS: 232-234-6
• Product Categories: Pharmaceutical Intermediates;Inorganics;GlycosidesChemical Synthesis;Inorganic AcidsDerivatization Reagents TLC;Steroids, Terpenes, Lipids, Bile acidsDerivatization Reagents TLC;Derivatization Reagents TLC;Synthetic Reagents;TLC Reagents, A-C;TLC Visualization Reagents (alphabetic sort);TLC Visualization Reagents (by application);Miscellaneous Reagents
• Mol File: 7790-94-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: -80°C
• Boiling Point: 151-152 °C755 mm Hg(lit.)
• Flash Point: 158°C
• Appearance: Yellow to brown/Oily Liquid, Fuming In Air
• Density: 1.753 g/mL at 25 °C(lit.)
• Vapor Density: 4 (vs air)
• Vapor Pressure: 1 mm Hg ( 25 °C)
• Refractive Index: n20/D 1.433(lit.)
• Storage Temp.: Room Temperature, under inert atmosphere
• Solubility: Miscible with hydrocarbons.
• PKA: -6.49±0.15(Predicted)
• Water Solubility: reacts
• Sensitive: Moisture Sensitive
• Stability: Stable, but reacts violently with water. In case of spills, mop up with sand - do not add water. Reacts with most metals to yiel
• Merck: 14,2165
• CAS DataBase Reference: Chlorosulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Chlorosulfonic acid(7790-94-5)
• EPA Substance Registry System: Chlorosulfonic acid(7790-94-5)

Safety Data

• Hazard Codes: C
• Statements: 14-35-37
• Safety Statements: 26-45
• RIDADR: UN 1754 8/PG 1
• WGK Germany: 1
• RTECS: FX5730000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: I
• Hazardous Substances Data: 7790-94-5(Hazardous Substances Data)

Usage

Chemical Description

Chlorosulfonic acid is used in the synthesis of derivatives 6 and 7.

InChI:InChI=1/ClHO3S/c1-5(2,3)4/h(H,2,3,4)

Upstream product

• 7664-93-9 sulfuric acid 
• 21926-53-4 4-methoxycarbonylamino-benzenesulfonyl chloride 
• 56-23-5 tetrachloromethane 
• 7783-05-3 disulfuric acid 
• 812-01-1 methyl chlorosulfate 
• 75-93-4 methyl bisulfate 
• 5402-73-3 2,5-dichlorobenzenesulphonyl chloride 
• 63113-57-5 3-sulfodiphenyl sulfone 
• 7782-50-5 chlorine 
• 7446-11-9 sulfur trioxide 
• 7704-34-9 sulfur 
• 67-66-3 chloroform 
• 10025-78-2 trichlorosilane 
• 608-73-1 1,2,3,4,5,6-hexachlorocyclohexane 

Downstream Products

• 69812-29-9 2-acetamido-4-methyl-5-thiazolesulfonyl chloride 
• 93783-15-4 3,3-dichloro-2-oxoindoline-5-sulfonyl chloride 
• 1513-44-6 2-amino-4-trifluoromethyl-benzenesulfonic acid 
• 100142-87-8 4-sulfamoyl-1,1'-biphenyl-4'-amine 
• 332361-07-6 5-phthalimidomethyl-thiophene-2-sulfonyl chloride 
• 1424-22-2 1-cyclohexenyl acetate 
• 98-82-8 Isopropylbenzene 
• 2010-06-2 2-Amino-4-phenylthiazole 
• 123-19-3 4-heptanone 
• 812-01-1 methyl chlorosulfate 
• 49715-04-0 chlorosulfuric acid chloromethyl ester 
• 75-44-5 phosgene 
• 41284-12-2 bis-(1,2,2,2-tetrachloro-ethyl)-ether 
• 507-20-0 tertiary butyl chloride 

Relevant articles and documents

Metalloprotease inhibitors

A compound selected from those of the formula (I): wherein: R1represents hydrogen or halogen, or alkyl or alkoxy, R2represents hydroxy, alkoxy or —NHOH, Ar1represents phenylene or biphenylene, X represents oxygen or sulphur, NR, —C≡C— or a bond, R represents hydrogen or alkyl, n is an integer from 0 to 6 inclusive, Ar2represents any one of the groups as defined in the description, its isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as metalloprotease inhibitors.