77921-03-0

Basic information

• Product Name: (E)-4-methyl-3-phenyl-2-pentenoic acid
• Synonyms: (E)-4-methyl-3-phenyl-2-pentenoic acid
• CAS NO: 77921-03-0
• Molecular Weight: 190.242
• Mol File: 77921-03-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-4-methyl-3-phenyl-2-pentenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-methyl-3-phenyl-2-pentenoic acid(77921-03-0)
• EPA Substance Registry System: (E)-4-methyl-3-phenyl-2-pentenoic acid(77921-03-0)

Safety Data

• Hazardous Substances Data: 77921-03-0(Hazardous Substances Data)

Upstream product

• 611-70-1 phenyl isopropyl ketone 
• 55164-19-7 ethyl-(Z)-3-chloro-3-phenyl-2-propenoate 
• 7664-93-9 sulfuric acid 
• 79238-27-0 4-methyl-3-phenyl-3-penten-1-oic acid 
• 62751-30-8 (E)-ethyl 4-methyl-3-phenylpent-2-enoate 
• 126275-04-5 ethyl (Z)-4-methyl-3-phenyl-2-pentenoate 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 51690-50-7 4-methyl-3-phenylpentanoic acid 
• 17498-71-4 3-methyl-2-phenyl-1-butene 
• 79238-27-0 4-methyl-3-phenyl-3-penten-1-oic acid 
• 22573-51-9 (S)-(-)-3-phenyl-4-methylpentanoic acid 
• 199468-80-9 (S)-3-((2R,3S)-2-Azido-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 175853-65-3 (R)-3-((2S,3R)-2-Azido-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 175853-64-2 (R)-3-((2R,3R)-2-Bromo-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 199468-77-4 (S)-3-((2S,3S)-2-Bromo-4-methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 176198-10-0 (4R,3'S)-4-phenyl-3-(3'-phenylisohexanyl)-2-oxazolidinone 
• 176018-92-1 (R)-3-((R)-4-Methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 176018-91-0 (S)-3-((S)-4-Methyl-3-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-one 
• 175853-63-1 (4S,3'R)-4-phenyl-3-(3'-phenylisohexanyl)-2-oxazolidinone 
• 199468-83-2 (2R,3S)-2-azido-3-phenylisohexanoic acid 
• 199468-81-0 (2S,3S)-2-azido-3-phenylisohexanoic acid 

Relevant articles and documents

Enantioselective Hydrogenation of β,β-Disubstituted Unsaturated Carboxylic Acids under Base-Free Conditions

An additive-free enantioselective hydrogenation of β,β-disubstituted unsaturated carboxylic acids catalyzed by the Rh-(R,R)-f-spiroPhos complex has been developed. Under mild conditions, a wide scope of β,β-disubstituted unsaturated carboxylic acids were hydrogenated to the corresponding chiral carboxylic acids with excellent enantioselectivities (up to 99.3% ee). This methodology was also successfully applied to the synthesis of the pharmaceutical molecule indatraline.

Steric Effects in the Synthesis of 1,7-Dialkylindans

Synthesis routes to 1-alkyl(CH3,C2H5,i-C3H7)-6-methylindans and 1-alkyl(CH3,C2H5,i-C3H7)-7-methylindans are described.Members of the latter series, especially 1-isopropyl-7-methylindan, are sterically hindered through a peri interaction.This effect manifests itself throughout the study and necessitated use of alternative synthesis routes.Yields in the Grignard, Peterson olefination, Reformatsky, and Wittig reactions as well as catalytic hydrogenation and Li/NH3 reduction of α,β-unsaturated acids were compared.