77970-53-7Relevant articles and documents
Oxidative Sulfonylation of Hydrazones Enabled by Synergistic Copper/Silver Catalysis
Xu, Jun,Shen, Chao,Qin, Xian,Wu, Jie,Zhang, Pengfei,Liu, Xiaogang
, p. 3706 - 3720 (2021/02/05)
A copper/silver-cocatalyzed protocol for oxidative sulfonylation of hydrazones is demonstrated. A wide range of β-ketosulfones and N-acylsulfonamides are directly synthesized in moderate to good yields. Our work provides a viable method for scalable preparation of β-ketosulfone derivatives that have found wide applications in the pharmaceutical industry.
Method for preparing beta-carbonyl sulfone compound by using half-sandwich iridium complex
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Paragraph 0062-0065, (2021/07/31)
The invention relates to a method for preparing a beta-carbonyl sulfone compound by using a half-sandwich iridium complex, which comprises the following step: in the presence of alkali, by taking acetophenone and sulfonyl chloride as raw materials and taking the half-sandwich iridium complex containing an o-carboborylbenzoxazole structure as a catalyst, conducting reacting at room temperature to prepare the beta-carbonyl sulfone compound. Compared with the prior art, the method has the advantages that the half-sandwich iridium complex containing the o-carboborylbenzoxazole structure is used as the catalyst, acetophenone and sulfonyl chloride are efficiently catalyzed to react under the room temperature condition to synthesize the beta-carbonyl sulfone compound, the product yield is high, the reaction condition is mild, the substrate is cheap and easy to obtain, and the catalytic efficiency is high.
Dioxygen-Triggered Oxosulfonylation/Sulfonylation of Terminal Olefins toward β-Keto Sulfones/Sulfones
Wang, Yanjie,Zhao, Yuhan,Cai, Changqun,Wang, Lingyun,Gong, Hang
supporting information, p. 8296 - 8301 (2021/11/13)
A dioxygen-triggered oxosulfonylation/sulfonylation of unactivated olefins to achieve β-keto sulfones/sulfones has been developed. Interestingly, pluralistic mechanisms were found when different types of compounds were applied as substrates, and different products were achieved. The reaction is carried out with a high atomic efficiency in the absence of a metal and a catalyst at room temperature under an air atmosphere. Importantly, as a proof-of-concept, a bioactive molecule was synthesized on a gram-scale level using this method.