77995-06-3

Basic information

• Product Name: Ethyl 2-(methylthio)-4-phenylpyrimidine-5-carboxylate
• Synonyms: Ethyl 2-(methylthio)-4-phenylpyrimidine-5-carboxylate;Ethyl 4-(4-fluorophenyl)-2-(methylamino)pyrimidine-5-carboxylate;ethyl 2-(methylsulfanyl)-4-phenylpyrimidine-5-carboxylate
• CAS NO: 77995-06-3
• Molecular Formula: C₁₄H₁₄N₂O₂S
• Molecular Weight: 274.33816
• Mol File: 77995-06-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 2-(methylthio)-4-phenylpyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(methylthio)-4-phenylpyrimidine-5-carboxylate(77995-06-3)
• EPA Substance Registry System: Ethyl 2-(methylthio)-4-phenylpyrimidine-5-carboxylate(77995-06-3)

Safety Data

• Hazardous Substances Data: 77995-06-3(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 867-44-7 S-Methylisothiourea sulfate 
• 14527-26-5 2-methylisothiourea sulphate 
• 78-84-2 isobutyraldehyde 
• 75-91-2 tert.-butylhydroperoxide 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 53114-57-1 S-methylisothiourea hydrochloride 

Downstream Products

• 56734-10-2 2-(methylsulfanyl)-4-phenylpyrimidine 
• 149771-15-3 2-Methylsulfanyl-4-phenyl-pyrimidine-5-carboxylic acid 

Relevant articles and documents

Efficient aerobic oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines

4-Substituted dihydropyrimidinones and dihydropyrimidines were first efficient aerobic oxidized to the corresponding pyrimidinones and pyrimidines, respectively, in high yields by molecular oxygen in the presence of catalytic amount of N-hydroxyphthalimid

Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines

(Chemical Equation Presented) A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO 3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.

An Improved General Synthesis of 4-Aryl-5-pyrimidinecarboxylates

We wish to report an improved, general synthesis of 4-aryl-5-pyrimidinecarboxylates 1.Two different routes have previously been reported for the synthesis of examples of this class of pyrimidine carboxylates.The parent compound, ethyl 4-phenyl-5-pyrimidinecarboxylate was prepared in low yield by the reaction of s-triazine with ethyl benzoyl acetate.In addition, the enol ether β-ketoaldehyde synthon, ethyl 2-benzoyl-3-ethoxy-2-propenoate, was reported to give 1a in modest yield when reacted with guanidine (2).