78-97-7 Usage
Chemical Properties
Lactonitrile, is soluble in water and alcohol, but insoluble in diethyl ether and carbon disulfide. Lactonitrile is used chiefly to manufacture lactic acid and its derivatives, primarily ethyl lactate.
Uses
Different sources of media describe the Uses of 78-97-7 differently. You can refer to the following data:
1. It is used primarily as a solvent, and as an
intermediate in production of ethyl acetate and lactic acid.
2. 2-Hydroxypropanenitrile is a useful compound for efficient lactamide synthesis by fed batch method using nitrile hydratase of Rhodococcus pyridinivorans NIT-36.
Production Methods
Different sources of media describe the Production Methods of 78-97-7 differently. You can refer to the following data:
1. Lactonitrile is derived from acetaldehyde and hydrocyanic
acid.
2. Lactonitrile is manufactured from equimolar amounts of acetaldehyde and hydrogen cyanide containing 1.5% of 20% NaOH at ?10–20 °C. The product is stabilized with sulfuric acid. Sulfuric acid hydrolyzes the nitrile to give a mixture of lactic acid and ammonium bisulfate. This mixture can be purified by adding methanol to form methyl lactate which is separated from the ammonium bisulfate. The methyl lactate is distilled, then hydrolyzed back to the aqueous acid. Removal of most of the water yields 90% lactic acid.
General Description
Straw colored liquid. Used as a solvent /intermediate in production of ethyl lactate and lactic acid.
Air & Water Reactions
Water soluble.
Reactivity Profile
Lactonitrile is incompatible with strong acids, strong bases and strong reducing agents. Lactonitrile is also incompatible with strong oxidizers. In the presence of alkali, Lactonitrile evolves toxic compounds. .
Health Hazard
Extremely toxic by oral, skin, or eye contact.
Fire Hazard
Cyanide fumes released when heated to decomposition. Avoid alkali, oxidizing material.
Check Digit Verification of cas no
The CAS Registry Mumber 78-97-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78-97:
(4*7)+(3*8)+(2*9)+(1*7)=77
77 % 10 = 7
So 78-97-7 is a valid CAS Registry Number.
78-97-7Relevant articles and documents
Photochemical reductive homologation of hydrogen cyanide using sulfite and ferrocyanide
Xu, Jianfeng,Ritson, Dougal J.,Ranjan, Sukrit,Todd, Zoe R.,Sasselov, Dimitar D.,Sutherland, John D.
supporting information, p. 5566 - 5569 (2018/06/04)
Photoredox cycling during UV irradiation of ferrocyanide ([FeII(CN)6]4-) in the presence of stoichiometric sulfite (SO32-) is shown to be an extremely effective way to drive the reductive homologation
2 - methyl malonic acid diester synthetic method of the compound
-
Paragraph 0033-0036, (2017/08/10)
The invention discloses a synthetic method of 2-diester methylmalonate compounds, and relates to the technical field of carboxylic ester preparation. The synthetic method comprises steps as follows: C, sulfonic acid 2-ethyl N-cyanoethanimideate IV and cyanide react under the action of a solvent and a catalyst, and 2-methyl malononitrile V is obtained; D, 2-methyl malononitrile V and ROH react under the action of the solvent and concentrated sulfuric acid, and products of 2-diester methylmalonate compounds I are obtained, wherein MCN is cyanide, M is Na or K, ROH is alkyl alcohol, alkenyl alcohol or a fluoride group containing alcohol, is benzyl alcohol or benzyl alkyl, halogen or nitro substituted benzyl alcohol, or is phenol or C1-C5 containing alkyl, halogen or nitro substituted phenol. The method is unique, the reaction conditions are mild, the reaction process is basically free of by-products, the yield is high, adopted raw materials have extensive sources, and acetaldehyde can be used as the raw material; the synthetic method is applicable to industrial production.
Method of manufacturing cyanohydrins
-
Paragraph 0072; 0073, (2016/12/26)
Disclosed is a process for producing a cyanohydrin, the process comprising reacting a carbonyl compound with hydrocyanic acid in a buffer solution with a pH less than 7 to obtain the cyanohydrin.