78007-47-3Relevant articles and documents
Synthesis of enamides related to the salicylate antitumor macrolides using copper-mediated vinylic substitution
Shen, Ruichao,Porco Jr., John A.
, p. 1333 - 1336 (2000)
(equation presented) A new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides. Modified reaction conditions have been developed to synthesize the O-methyloxime enamide side chai
A convenient synthesis of N-vinyl enamides via the lithiation and ring-opening reaction of 2-phenyl-2-oxazolines
Xu, Yi,Liu, Xiao-Yu,Wang, Zi-Qi,Tang, Liang-Fu
, p. 1788 - 1791 (2017/04/13)
A simple and efficient synthesis of N-vinyl enamides via the lithiation and ring-opening reaction of 2-phenyl-2-oxazolines with lithium diisopropylamide at room temperature has been developed. This method is especially suitable for the synthesis of multif
Cesium hydroxide-mediated regio- and stereoselective hydroamidation of internal aryl alkynes with primary amides
Yamamoto, Chiaki,Hirano, Koji,Miura, Masahiro
supporting information, p. 1048 - 1050 (2017/06/28)
A cesium hydroxide-mediated hydroamidation of internal aryl alkynes with primary amides has been developed. The reaction proceeds with high anti-selectivity to deliver the corresponding stereodefined (Z)-enamides in good yields. The alkali base-promoted system is also compatible with unsymmetrical aryl alkyl alkynes, and the hydroamidated products are obtained with high regioselectivity as well as stereoselectivity.