78008-15-8

Basic information

• Product Name: 3-(TRIFLUOROACETYLAMINO)-1-PROPANOL
• Synonyms: 3-(TRIFLUOROACETAMIDO)PROPAN-1-OL;3-(TRIFLUOROACETYLAMINO)-1-PROPANOL;N-TRIFLUOROACETYL-3-AMINO-1-PROPANOL;N-TRIFLUOROACETYL-BETA-ALANINOL;N-(3-HYDROXYPROPYL)TRIFLUOROACETAMIDE;TFA-NH-(CH2)3-OH;TFA-B-ALA-OL;TFA-BETA-ALA-OL
• CAS NO: 78008-15-8
• Molecular Formula: C₅H₈F₃NO₂
• Molecular Weight: 171.12
• Product Categories: Amino Alcohols;Bifunctional Crosslinkers;Building Blocks;Chemical Biology;Chemical Synthesis;Linkers;Organic Building Blocks;Oxygen Compounds;Peptide Chemistry
• Mol File: 78008-15-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 120-121 °C0.03 mm Hg(lit.)
• Flash Point: 105 °C
• Appearance: /
• Density: 1.355 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.00353mmHg at 25°C
• Refractive Index: n20/D 1.406
• BRN: 4969338
• CAS DataBase Reference: 3-(TRIFLUOROACETYLAMINO)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(TRIFLUOROACETYLAMINO)-1-PROPANOL(78008-15-8)
• EPA Substance Registry System: 3-(TRIFLUOROACETYLAMINO)-1-PROPANOL(78008-15-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 78008-15-8(Hazardous Substances Data)

Usage

General Description

3-(Trifluoroacetylamino)-1-propanol is a fluorinated alcohol compound with the chemical formula C5H9F3NO2. It is a clear, colorless liquid with a molecular weight of 161.12 g/mol. This chemical is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and active pharmaceutical ingredients. It is also utilized as a reagent in organic chemical reactions, particularly in the production of fluorinated compounds. Additionally, 3-(Trifluoroacetylamino)-1-propanol has potential applications in the field of agrochemicals, as well as in the development of new materials and fluorescent probes. However, due to its potential hazards and toxicity, it should be handled and used with caution, following appropriate safety protocols and guidelines.

InChI:InChI=1/C5H8F3NO2/c6-5(7,8)4(11)9-2-1-3-10/h10H,1-3H2,(H,9,11)

Upstream product

• 38182-16-0 N-methyl N-cyclohexyl trifluoroacetamide 
• 156-87-6 propan-1-ol-3-amine 
• 354-32-5 trifluoracetyl chloride 
• 407-25-0 trifluoroacetic anhydride 
• 1339837-81-8 2,2,2-trifluoro-N-[3-(vinyloxy)propyl]acetamide 
• 1415392-93-6 N,N′-[ethane-1,1-diylbis(oxypropane-3,1-diyl)]bis(2,2,2-trifluoroacetamide) 
• 109317-75-1 4-trifluoroacetyl-2,3-dihydrofuran 
• 383-63-1 ethyl trifluoroacetate, 
• 431-47-0 trifluoroacetic acid-methyl ester 

Downstream Products

• 196951-45-8 methyl [(3-trifluoroacetamidopropyl)-5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-α-D-glycero-D-galacto-pyranoside]-2-nonulosonate 
• 497869-65-5 3-trifluoroacetamidopropyl (2-acetamido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-β-D-mannopyranosyl)-(1->4)-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-(1->2)-3,4-di-O-benzyl-α-L-rhamnopyranoside 
• 497869-75-7 3-trifluoroacetamidopropyl (2-acetamido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-β-D-mannopyranosyl)-(1->4)-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-(1->2)-3,4-di-O-benzyl-β-L-rhamnopyranoside 
• 67680-57-3 1-iodo-3-(trifluoroacetylamino)propane 
• 1042665-02-0 N-[3-(chloromethoxy)propyl]-2,2,2-trifluoroacetamide 
• 105-57-7 diethyl acetal 
• 1415392-93-6 N,N′-[ethane-1,1-diylbis(oxypropane-3,1-diyl)]bis(2,2,2-trifluoroacetamide) 
• 1415392-88-9 N-[3-(1-ethoxyethoxy)propyl]-2,2,2-trifluoroacetamide 
• 871-22-7 dibutyl acetal 
• 1415392-89-0 N-[3-(1-butoxyethoxy)propyl]-2,2,2-trifluoroacetamide 
• 1670-47-9 1,1-diethoxycyclohexane 
• 1415392-95-8 N,N'-[cyclohexane-1,1-diylbis(oxypropane-3,1-diyl)]bis(2,2,2-trifluoroacetamide) 
• 329790-65-0 methanesulfonic acid 3-(2,2,2-trifluoroacetylamino)-propyl ester 
• 100496-19-3 3-trifluoroacetamidopropyl 2-azido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 

Relevant articles and documents

Phosphine-Catalyzed Synthesis of Chiral N-Heterocycles through (Asymmetric) P(III)/P(V) Redox Cycling

Phosphine-catalyzed tandem Michael addition/intramolecular Wittig reactions have been developed for the synthesis of chiral 2,5-dihydro-1H-pyrrole and tetrahydropyridine derivatives. These processes have been rendered catalytic in phosphine, thanks to the in situ reduction of phosphine oxide by phenylsilane. Furthermore, catalytic and asymmetric P(III)/P(V) processes were implemented using enantiopure chiral phosphines.

Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels

The effect of structural variations in acetal- and ketal-based linkers upon their degradation kinetics is studied through the design, synthesis, and study of six series of molecules, comprising a total of 18 different molecules. Through this systematic study, we show that the structural fine-tuning of the linkers allows access to variations in kinetics of degradation of more than 6 orders of magnitude. Hammett correlations show that the ρ value for the hydrolysis of benzylidene acetals is about ?4.06, which is comparable to an SN1-like process. This shows that there is a strong, developing positive charge at the benzylic position in the transition state during the degradation of acetals. This positively charged transition state is consistent with the relative degradation rates of acetals vs ketals (correlated to stabilities of 1°, 2°, and 3° carboxonium ion type intermediates) and the observed effect of proximal electron-withdrawing groups upon the degradation rates. Following this, we studied whether the degradation kinetics study correlates with pH-sensitive variations in the host-guest characteristics of polymeric nanogels that contains these acetal or ketal moieties as cross-linking functionalities. Indeed, the trends observed in the small molecule degradation have clear correlations with the encapsulation stability of guest molecules within these polymeric nanogels. The implications of this fundamental study extend to a broad range of applications, well beyond the polymeric nanogel examples studied here.

Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming

A series of hybrid compounds was designed to target histone deacetylases and ds-/G-quadruplex DNAs by merging structural features deriving from Scriptaid and compound 1. Compound 6 binds different DNA arrangements, inhibits HDACs both in vitro and in cells, and is able to induce a reduction of cell proliferation. Moreover, compound 6 displays cell phenotype-reprogramming properties since it prevents the epithelial to mesenchymal transition in cancer cells, inducing a less aggressive and migratory phenotype, which is one of the goals of present innovative strategies in cancer therapies.