78071-37-1Relevant articles and documents
p-diaminobenzene derivative as potassium channel regulator, preparation method and medical applications thereof
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Paragraph 0197-0201, (2019/12/09)
The invention relates to a p-diaminobenzene derivative as a potassium channel regulator, a preparation method and medical applications thereof, and specifically discloses a compound represented by a general formula A or a pharmaceutically acceptable salt
PIPERIDINYLOXY LACTONE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 51; 52, (2015/07/07)
The present invention is directed to piperidinyloxy lactone compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the piperidinyloxy lactone compounds described herein in the potential treatment or preventi
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells
Pierre, Fabrice,Regan, Collin F.,Chevrel, Marie-Claire,Siddiqui-Jain, Adam,MacAlino, Diwata,Streiner, Nicole,Drygin, Denis,Haddach, Mustapha,O'Brien, Sean E.,Rice, William G.,Ryckman, David M.
scheme or table, p. 3327 - 3331 (2012/06/18)
A novel family of potent dual inhibitors of CK2 and the Pim kinases was discovered by modifying the scaffolds of tricyclic Pim inhibitors. Several analogs were active at single digit nanomolar IC50 values against CK2 and the Pim isoforms Pim-1