780782-31-2Relevant articles and documents
2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines
Gommermann, Nina,Knochel, Paul
, p. 4175 - 4177 (2005)
2-Phenallyl was found to be a versatile protecting group of primary amines for the asymmetric one-pot three-component synthesis of propargylamines which leads to enantiomeric excess of up to 96%; it can be easily removed with a palladium(0)-catalyzed ally
Synthesis of chiral α-aminoalkylpyrimidines using an enantioselective three-component reaction
Dube, Henry,Gommermann, Nina,Knochel, Paul
, p. 2015 - 2025 (2007/10/03)
A range of chiral α-aminoalkylpyrimidines has been prepared in a modular fashion in 5 steps with up to 98% ee. The key step is a CuBr-catalyzed enantioselective asymmetric three-component synthesis of propargylic amines.