78155-76-7Relevant articles and documents
1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS
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Page/Page column 66-67, (2010/02/10)
The invention provides compounds of the formula: (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a MAPKAP kinase: wherein A is a bond or a group CH2; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra -Rbwherein Ra is a bond, 0, CO, X1C(X2), C(X2)Xl, X1C(X2)X1, S, SO, S02, NRc, SO2NRc or NRcS02; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, amino, mono or di-C1-4 hydrocarbylamino, carbocyclic and heterocyclic groups having from 3 to 12 ring members and wherein one or more carbon atoms of the C1-8 hydrocarbyl group may optionally be replaced by 0, S, SO, SO2, NRc, X1C(X2), C(X2)X1 or X1C(X2)X1; Rc is hydrogen or C1-4hydrocarbyl; and X1 is O, S or NRc and X2 is =O, =S or =NRc.
SEMICARBAZONES AND THIOSEMICARBAZONES OF THE HETEROCYCLIC SERIES
Tomchin, A. B.,Tumanova, I. V.
, p. 1146 - 1148 (2007/10/02)
When heated with an aqueous solution of potassium carbonate, 5-nitroisatin 3-thiosemicarbazone does not form 8-nitro-1,2,4-triazinoindole-3-thione, as indicated earlier, but forms 6-(2-amino-5-nitrophenyl)-5-oxo-1,2,4-triazine-3-thione and 5-nitro-
