78162-58-0

Basic information

• Product Name: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
• Synonyms: N,N-DIMETHYL IMIDAZOLE-1-SULFONAMIDE;IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE;1-(DIMETHYLSULFAMOYL)IMIDAZOLE;N,N-Dimethyl-1H-imidazole-1-sulphonamide;N,N-Dimethyl-1H-imidazole-1-sulfonamide;1-(Dimethylsulphamoyl)-1H-imidazole;1-(Dimethylsulphamoyl)-1H-imidazole, 1-[(Dimethylamino)sulphonyl]-1H-imidazole;1-(N,N-Dimethylsulfamoyl)-1H-imidazole
• CAS NO: 78162-58-0
• Molecular Formula: C₅H₉N₃O₂S
• Molecular Weight: 175.21
• Product Categories: blocks;Imidazoles;Sulfonamides;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks
• Mol File: 78162-58-0.mol
• Article Data: 30

Chemical Properties

• Melting Point: 48-51 °C(lit.)
• Boiling Point: 307.2°C at 760 mmHg
• Flash Point: 230 °F
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 0.000737mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 2.41±0.10(Predicted)
• CAS DataBase Reference: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE(78162-58-0)
• EPA Substance Registry System: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE(78162-58-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 78162-58-0(Hazardous Substances Data)

Usage

Description

IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE, also known as 1-(N,N-Dimethylsulfamoyl)-1H-imidazole, is an Imidazole (I350200) derivative with a sulfonic acid group and a dimethyl amine group. It is a versatile chemical compound that can be used in the synthesis of various pharmaceutical agents and drug-like compounds.

Uses

Used in Pharmaceutical Industry:
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is used as a key intermediate in the preparation of Histamine H3 Receptor Agonists. These agonists are important in the development of drugs targeting the histaminergic system, which plays a crucial role in various physiological processes, including wakefulness, appetite regulation, and immune response.
Used in Drug Synthesis:
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is also used in the synthesis of drug-like angiotensin II compounds with affinity for the AT2 receptor. Angiotensin II is a potent vasoconstrictor that plays a significant role in the regulation of blood pressure and fluid balance. The development of compounds with affinity for the AT2 receptor may lead to novel therapeutic agents for the treatment of hypertension and other cardiovascular diseases.
Used in Organic Synthesis:
Furthermore, IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE can be used to synthesize 1-(dimethylsulfamoyl)-2-imidazolecarboxaldehyde, a compound that may have potential applications in various organic synthesis processes. IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE can be further modified or used as a building block for the development of new pharmaceutical agents or other chemical products.

InChI:InChI=1/C5H9N3O2S/c1-7(2)11(9,10)8-4-3-6-5-8/h3-5H,1-2H3

Upstream product

• 288-32-4 1H-imidazole 
• 13360-57-1 dimethylamino sulfonyl chloride 
• 124-40-3 dimethyl amine 
• 489471-57-0 3-(imidazole-1-sulfonyl)-1-methyl-3H-imidazol-1-ium triflate 
• 129378-52-5 2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide 

Downstream Products

• 129378-52-5 2-tert-butyldimethylsilyl-N,N-dimethylimidazole-1-sulfonamide 
• 149647-72-3 1-(N,N-dimethylsulfamoyl)-2-(tert-butyldimethylsilyl)-5-(4-chlorobutyl)imidazole 
• 138867-04-6 1-N,N-Dimethylsulfamoyl-2-(tert-butyldimethylsilyl)-5-(2,3-dimethylbenzoyl)imidazole 
• 123914-19-2 1-(N,N-dimethylsulfamoyl)-2-phenylthio-1H-imidazole 
• 936336-89-9 N,N-dimethyl-(2-triisopropylsilanylimidazole)-1-sulfonamide 
• 868287-76-7 3-(1-(dimethylsulfamoyl)-1H-imidazol-2-yl)-5-(5-((R)-2-teit-butoxycarbonylamino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-N-(methylsulfonyl)benzenamine 
• 942070-58-8 N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole-1-sulfonamide 
• 54925-64-3 N-(tert-butyldimethylsilyl)imidazole 
• 945407-69-2 2-(tert-butyl-dimethyl-silanyl)-4-(hydroxy-phenyl-methyl)-imidazole-1-sulfonic acid dimethylamide 
• 140174-48-7 4-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide 
• 611-74-5 N,N-dimethylbenzamide 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 14062-78-3 N,N-dimethyl-4-toluamide 
• 7291-01-2 N,N-dimethyl-4-nitrobenzamide 

Relevant articles and documents

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